Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0198 | 0.7914 | 1 |
Giardia lamblia | Rrm3p helicase | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0055 | 0.0001 | 0.0002 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0198 | 0.7914 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0055 | 0.0001 | 0.0002 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0055 | 0.0001 | 0.0002 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0055 | 0 | 0.5 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0055 | 0.0001 | 0.0002 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0055 | 0.0001 | 0.0002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0 | 0.5 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0055 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0055 | 0.0001 | 0.0002 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0055 | 0 | 0.5 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0055 | 0 | 0.5 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0055 | 0.0001 | 0.0002 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0055 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0055 | 0.0001 | 0.0002 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0181 | 0.6973 | 0.881 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0189 | 0.7456 | 0.942 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0055 | 0.0001 | 0.0002 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0055 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0189 | 0.7456 | 0.942 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0181 | 0.6973 | 0.881 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0055 | 0.0001 | 0.0002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logD | = 1.93 | Tested for the 1-Octanol distribution coefficient determined by HPLC method (pH 7.4) | ChEMBL. | 6124635 |
pA2 (functional) | = 4.33 | Antagonistic activity against Alpha-1 adrenergic receptor in the epidermal portion of the rat vas deferens | ChEMBL. | 6124635 |
pA2 (functional) | = 6.2 | Antagonistic activity against Alpha-2 adrenergic receptor in the prostatic portion of the rat vas deferens | ChEMBL. | 6124635 |
Selectivity ratio (binding) | = 74.1 | Selectivity ratio is the ratio between pA2 values of alfa2 and alfa1 adrenoceptors | ChEMBL. | 6124635 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.