Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.1849 | 1 | 0.5 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.1849 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1849 | 1 | 0.5 |
Leishmania major | developmentally regulated phosphoprotein-like protein | 0.1849 | 1 | 0.5 |
Trypanosoma brucei | developmentally regulated phosphoprotein | 0.1849 | 1 | 0.5 |
Trypanosoma cruzi | developmentally regulated phosphoprotein, putative | 0.1849 | 1 | 0.5 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.1849 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0749 | 0 | 0.5 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.1849 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | 0 uM | Concentration producing 50% inhibition of Bacillus subtilis DNA topoisomerase III in the absence of dATP using DNA Polymerase assay; NA=Inactive | ChEMBL. | 3084785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.