Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0713 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.044 | 0.5262 | 0.5262 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0713 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0713 | 1 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0219 | 0.1418 | 0.0704 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0713 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0354 | 0.376 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.044 | 0.5262 | 0.5262 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0713 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0713 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0359 | 0.3854 | 0.3343 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0372 | 0.4075 | 0.4075 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0182 | 0.0768 | 0.0768 |
Echinococcus multilocularis | integrin beta 2 | 0.0276 | 0.24 | 0.2376 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0713 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0632 | 0.8592 | 0.8159 |
Brugia malayi | flavodoxin family protein | 0.0273 | 0.2352 | 0.2352 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0713 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.044 | 0.5262 | 0.4868 |
Loa Loa (eye worm) | integrin beta-2 | 0.0372 | 0.4075 | 0.4075 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0273 | 0.2352 | 0.2352 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0273 | 0.2352 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0713 | 1 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0276 | 0.24 | 0.2376 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0273 | 0.2352 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0713 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0273 | 0.2352 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.044 | 0.5262 | 0.5247 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0354 | 0.376 | 0.3241 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0713 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0273 | 0.2352 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0713 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0713 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0713 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0632 | 0.8592 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.044 | 0.5262 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0713 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0632 | 0.8592 | 0.8159 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0354 | 0.376 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0713 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0713 | 1 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.028 | 0.2476 | 0.2476 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0632 | 0.8592 | 0.8159 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0713 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.044 | 0.5262 | 0.5247 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0713 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0273 | 0.2352 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.009 | 0.009 |
Leishmania major | p450 reductase, putative | 0.0713 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0632 | 0.8592 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0713 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0273 | 0.2352 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.2 uM | Test against PAF-induced aggregation of rabbit platelets in vitro | ChEMBL. | 7861415 |
Inhibition (functional) | = 24 % | Ability to inhibit histamine-induced contractions of isolated guinea pig ileum at 10e-5 M | ChEMBL. | 7861415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.