Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | telomerase reverse transcriptase, putative | 0.3041 | 0.2682 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.3041 | 0.2682 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.3041 | 0.2682 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.3041 | 0.2682 | 0.5 |
Brugia malayi | hypothetical protein | 0.0124 | 0.0044 | 0.0054 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.3041 | 0.2682 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.3041 | 0.2682 | 0.5 |
Echinococcus granulosus | protection of telomeres protein 1 | 0.063 | 0.0501 | 0.5 |
Brugia malayi | hypothetical protein | 0.0124 | 0.0044 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0005 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0005 | 0.1141 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.063 | 0.0501 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0044 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.3041 | 0.2682 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.3041 | 0.2682 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0044 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.8092 | 0.725 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.0044 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1670 uM | Inhibition potency against Cholecystokinin-8-Inactivating Peptidase (Serine Peptidase). | ChEMBL. | 10691692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.