Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase type II | 0.0184 | 0.252 | 1 |
Onchocerca volvulus | 0.0184 | 0.252 | 1 | |
Onchocerca volvulus | 0.0184 | 0.252 | 1 | |
Brugia malayi | hexokinase | 0.0184 | 0.252 | 1 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0387 | 1 | 1 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0387 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0184 | 0.252 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0184 | 0.252 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0184 | 0.252 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0184 | 0.252 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0184 | 0.252 | 0.5 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0387 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0184 | 0.252 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0184 | 0.252 | 0.5 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0387 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0184 | 0.252 | 1 |
Schistosoma mansoni | hexokinase | 0.0184 | 0.252 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0184 | 0.252 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0184 | 0.252 | 0.5 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0387 | 1 | 1 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0387 | 1 | 1 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0387 | 1 | 1 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0184 | 0.252 | 1 |
Onchocerca volvulus | 0.0184 | 0.252 | 1 | |
Echinococcus granulosus | hexokinase | 0.0184 | 0.252 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0184 | 0.252 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.037 | 0.1468 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0184 | 0.252 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative activity (functional) | = 27 % | Relative activity for inhibition of rat liver vitamin K dependent carboxylase mediated carboxylation of pentapeptide at 1 mM. | ChEMBL. | 7252980 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.