Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0914 | 0.2347 | 0.2347 |
Brugia malayi | Kringle domain containing protein | 0.0914 | 0.2347 | 0.236 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0401 | 0.0849 | 0.085 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.0849 | 0.085 |
Echinococcus granulosus | Mastin | 0.0401 | 0.0849 | 0.2874 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Brugia malayi | Trypsin family protein | 0.0401 | 0.0849 | 0.085 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0401 | 0.0849 | 0.2874 |
Onchocerca volvulus | 0.0401 | 0.0849 | 0.085 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0914 | 0.2347 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0401 | 0.0849 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.0849 | 0.085 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0914 | 0.2347 | 0.236 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0401 | 0.0849 | 0.2874 |
Onchocerca volvulus | 0.0401 | 0.0849 | 0.085 | |
Onchocerca volvulus | 0.3508 | 0.9928 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0914 | 0.2347 | 0.236 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.0245 | 0.0241 |
Echinococcus multilocularis | enteropeptidase | 0.0401 | 0.0849 | 0.2874 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0401 | 0.0849 | 0.0849 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0401 | 0.0849 | 0.2874 |
Echinococcus granulosus | enteropeptidase | 0.0401 | 0.0849 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.0849 | 0.085 |
Onchocerca volvulus | 0.0195 | 0.0245 | 0.0241 | |
Onchocerca volvulus | 0.0401 | 0.0849 | 0.085 | |
Loa Loa (eye worm) | hypothetical protein | 0.3508 | 0.9928 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0401 | 0.0849 | 0.2874 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0914 | 0.2347 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0914 | 0.2347 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Schistosoma mansoni | hypothetical protein | 0.0401 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0914 | 0.2347 | 0.236 |
Onchocerca volvulus | 0.0914 | 0.2347 | 0.236 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Brugia malayi | Trypsin family protein | 0.0401 | 0.0849 | 0.085 |
Schistosoma mansoni | hypothetical protein | 0.0401 | 0.0849 | 0.0849 |
Onchocerca volvulus | 0.0401 | 0.0849 | 0.085 | |
Toxoplasma gondii | kringle domain-containing protein | 0.0914 | 0.2347 | 0.5509 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.0886 | 0.0886 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Toxoplasma gondii | PAN domain-containing protein | 0.15 | 0.4061 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.0401 | 0.0849 | 0.085 |
Brugia malayi | Trypsin family protein | 0.0401 | 0.0849 | 0.085 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0401 | 0.0849 | 0.2874 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0401 | 0.0849 | 0.2874 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0401 | 0.0849 | 0.2874 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0401 | 0.0849 | 0.085 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0914 | 0.2347 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0914 | 0.2347 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.0245 | 0.0245 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.0245 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.3508 | 0.9928 | 0.9928 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.0245 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Brugia malayi | thymidylate synthase | 0.0195 | 0.0245 | 0.0241 |
Brugia malayi | Trypsin family protein | 0.3508 | 0.9928 | 1 |
Echinococcus multilocularis | Mastin | 0.0401 | 0.0849 | 0.2874 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.0245 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3508 | 0.9928 | 1 |
Onchocerca volvulus | 0.3106 | 0.8755 | 0.8818 | |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.0849 | 0.085 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.0849 | 0.085 |
Toxoplasma gondii | PAN domain-containing protein | 0.15 | 0.4061 | 1 |
Onchocerca volvulus | 0.0401 | 0.0849 | 0.085 | |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0401 | 0.0849 | 0.2874 |
Brugia malayi | hypothetical protein | 0.0401 | 0.0849 | 0.085 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0914 | 0.2347 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0401 | 0.0849 | 0.0849 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.11 uM | In vitro inhibitory activity against thymidylate synthase partially purified from L1210 mouse leukemia cells | ChEMBL. | 8576912 |
IC50 (binding) | = 0.11 uM | In vitro inhibitory activity against thymidylate synthase partially purified from L1210 mouse leukemia cells | ChEMBL. | 8576912 |
IC50 (functional) | = 0.58 uM | In vitro inhibitory activity against L1210 cell growth | ChEMBL. | 8576912 |
IC50 (functional) | = 0.58 uM | In vitro inhibitory activity against L1210 cell growth | ChEMBL. | 8576912 |
Ratio (functional) | = 1.1 | Relative resistant ratio of compound as L1210:1565 IC50 over L1210 IC50 | ChEMBL. | 8576912 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 8576912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.