Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0343 | 0.4584 | 1 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.035 | 0.4742 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0554 | 0.9326 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0554 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.035 | 0.4742 | 0.0000097958 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0584 | 1 | 1 |
Brugia malayi | valosin containing protein | 0.0343 | 0.4584 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0584 | 1 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0554 | 0.9326 | 0.5 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0584 | 1 | 0.5 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0554 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0584 | 1 | 1 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0554 | 0.9326 | 0.5 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0584 | 1 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0343 | 0.4584 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0343 | 0.4584 | 1 |
Giardia lamblia | AAA family ATPase | 0.035 | 0.4742 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0554 | 0.9326 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0554 | 0.9326 | 0.9122 |
Mycobacterium ulcerans | ATPase | 0.035 | 0.4742 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0554 | 0.9326 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cyotoxicity (functional) | 0 | Tested for cytotoxicity against murine L1210 cells in vitro; weak cytotoxicity | ChEMBL. | 2299637 |
ID50 (functional) | = 0.1 ug ml-1 | In vitro antiviral activity of the compound against herpes simplex virus type-1 in vero cells | ChEMBL. | 2709380 |
ID50 (functional) | = 1 ug ml-1 | Dose to inhibit plaque formation in vero cells infected with herpes simplex virus type1(HSV-1,strainJLJ) was determined relative to acyclovir; value ranges from 0.1-1.0 ug/mL | ChEMBL. | 2299637 |
Survival (functional) | = 24.3 % | In vitro cytotoxicity of the compound against L1210 cells at a dose 50 microg/mL | ChEMBL. | 2709380 |
Survival (functional) | = 74 % | In vitro cytotoxicity of the compound against L1210 cells at a dose 10 microg/mL | ChEMBL. | 2709380 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.