Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0753 | 0.9591 | 0.9591 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0376 | 0.0212 | 0.0212 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0753 | 0.9591 | 0.9591 |
Schistosoma mansoni | glutamate receptor kainate | 0.0668 | 0.7486 | 0.9328 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0667 | 0.746 | 0.9272 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0376 | 0.0212 | 0.0212 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0384 | 0.0409 | 0.0409 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0681 | 0.78 | 0.78 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0685 | 0.7895 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0685 | 0.7895 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0769 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0576 | 0.5196 | 0.5196 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0462 | 0.2343 | 0.2343 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0384 | 0.0409 | 0.0409 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0769 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0753 | 0.9591 | 0.9591 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0753 | 0.9591 | 0.9591 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0576 | 0.5196 | 0.5196 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0769 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0753 | 0.9591 | 0.9591 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0681 | 0.78 | 0.78 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0753 | 0.9591 | 0.9591 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0685 | 0.7895 | 0.7895 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0685 | 0.7895 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0681 | 0.78 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0668 | 0.7486 | 0.9328 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 13 % | Percent inhibition of Catechol O-methyltransferase activity in rat brain at dose of 30 mg/kg determined at 6 h after its administration | ChEMBL. | 11806720 |
Inhibition (binding) | = 13 % | Percent inhibition of Catechol O-methyltransferase activity in rat brain at dose of 30 mg/kg determined at 6 h after its administration | ChEMBL. | 11806720 |
Inhibition (binding) | = 15 % | Percent inhibition of Catechol O-methyltransferase activity in rat brain at dose of 30 mg/kg determined at 9 h after its administration | ChEMBL. | 11806720 |
Inhibition (binding) | = 15 % | Percent inhibition of Catechol O-methyltransferase activity in rat brain at dose of 30 mg/kg determined at 9 h after its administration | ChEMBL. | 11806720 |
Inhibition (binding) | = 18 % | Percent inhibition of Catechol O-methyltransferase activity in rat liver at dose of 30 mg/kg determined at 9 h after its administration | ChEMBL. | 11806720 |
Inhibition (binding) | = 18 % | Percent inhibition of Catechol O-methyltransferase activity in rat liver at dose of 30 mg/kg determined at 9 h after its administration | ChEMBL. | 11806720 |
Inhibition (binding) | = 48 % | Percent inhibition of Catechol O-methyltransferase activity in rat liver at dose of 30 mg/kg determined at 6 hr after its administration | ChEMBL. | 11806720 |
Inhibition (binding) | = 48 % | Percent inhibition of Catechol O-methyltransferase activity in rat liver at dose of 30 mg/kg determined at 6 hr after its administration | ChEMBL. | 11806720 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.