TDR Targets

Basic information

Technical information

TDR Targets ID: 276405
Name: N'-[(3-chlorophenyl)methyl]naphthalene-2-carb oximidamide
MW: 294.778 | Formula: C18H15ClN2
H donors: 1 H acceptors: 0 LogP: 4.66 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)CNC(=N)c1ccc2c(c1)cccc2
InChi: 1S/C18H15ClN2/c19-17-7-3-4-13(10-17)12-21-18(20)16-9-8-14-5-1-2-6-15(14)11-16/h1-11H,12H2,(H2,20,21)
InChiKey: BUXIFKWPTDKUGN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-[(3-chlorophenyl)methyl]naphthalene-2-carboxamidine
N'-[(3-chlorophenyl)methyl]-2-naphthalenecarboxamidine
N'-(3-chlorobenzyl)-2-naphthamidine
N'-(3-chlorobenzyl)naphthalene-2-carboxamidine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, ionotropic, N-methyl D-aspartate 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma mansoni	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.1337	0.1669
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.1337	0.1337
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.1337	0.1669
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.1337	0.1337
Echinococcus granulosus	g protein coupled receptor	0.0038	0.1337	0.1669
Schistosoma mansoni	opsin-like receptor	0.0038	0.1337	0.1337
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.1337	1
Echinococcus granulosus	nmda type glutamate receptor	0.0104	0.801	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	somatostatin receptor	0.0038	0.1337	0.1669
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.1337	0.1337
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Onchocerca volvulus		0.0038	0.1337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0461	0.0575
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Echinococcus granulosus	hypothetical protein	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.1337	0.1669
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0461	0.0575
Brugia malayi	putative neuropeptide receptor	0.0038	0.1337	1
Brugia malayi	larval opioid receptor	0.0038	0.1337	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.1337	0.1669
Echinococcus granulosus	fmrfamide receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0029	0.0461	0.0575
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.1337	0.1337
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.1337	0.1669
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.1337	0.1669
Onchocerca volvulus		0.0038	0.1337	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.1337	0.1669
Brugia malayi	G-protein coupled receptor	0.0038	0.1337	1
Schistosoma mansoni	amine GPCR	0.0038	0.1337	0.1337
Schistosoma mansoni	biogenic amine receptor	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.1337	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.1337	0.1669
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.1337	0.1337
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.1337	0.1669
Onchocerca volvulus		0.0038	0.1337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.1337	0.1669
Onchocerca volvulus		0.0038	0.1337	0.5
Schistosoma mansoni	hypothetical protein	0.0038	0.1337	0.1337
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.1337	1
Schistosoma mansoni	hypothetical protein	0.0038	0.1337	0.1337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.1337	0.1337
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.1337	0.1337
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.1337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.1337	0.1337
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.1337	0.1669
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.1337	0.1669
Onchocerca volvulus		0.0038	0.1337	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.1337	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Onchocerca volvulus		0.0038	0.1337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	hypothetical protein	0.0038	0.1337	0.1337
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.1337	0.1337
Brugia malayi	G protein-coupled receptor	0.0038	0.1337	1
Schistosoma mansoni	opsin-like receptor	0.0038	0.1337	0.1337
Echinococcus multilocularis	serotonin receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.1337	1
Echinococcus multilocularis	nmda type glutamate receptor	0.01	0.7572	0.9453
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.1337	0.1337
Echinococcus granulosus	orexin receptor type 2	0.0038	0.1337	0.1669
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.1337	0.1669
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.1337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	amine GPCR	0.0038	0.1337	0.1337
Onchocerca volvulus		0.0038	0.1337	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.1337	0.1337
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.1337	0.1669
Schistosoma mansoni	neuropeptide receptor	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.1337	0.1669
Schistosoma mansoni	neuropeptide receptor	0.0038	0.1337	0.1337
Echinococcus granulosus	sex peptide receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.1337	0.1669
Schistosoma mansoni	amine GPCR	0.0038	0.1337	0.1337
Brugia malayi	G-protein coupled receptor	0.0038	0.1337	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.1337	0.1669
Echinococcus multilocularis	serotonin receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.1337	0.1669
Onchocerca volvulus		0.0038	0.1337	0.5
Echinococcus multilocularis	sex peptide receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	glutamate receptor NMDA	0.0095	0.7112	0.8879
Brugia malayi	GnHR receptor homolog	0.0038	0.1337	1
Schistosoma mansoni	biogenic amine receptor	0.0038	0.1337	0.1337
Onchocerca volvulus		0.0038	0.1337	0.5
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0461	0.0575
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.1337	0.1669
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.1337	0.1669
Brugia malayi	sulfakinin receptor protein	0.0038	0.1337	1
Onchocerca volvulus		0.0038	0.1337	0.5
Brugia malayi	RE15519p	0.0038	0.1337	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.1337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.1337	0.1337
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.1337	0.1669
Brugia malayi	Serotonin receptor	0.0038	0.1337	1
Brugia malayi	Dopamine receptor	0.0038	0.1337	1
Echinococcus granulosus	g protein coupled receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.1337	0.1669
Schistosoma mansoni	myosin xvIII	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Onchocerca volvulus		0.0038	0.1337	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.1337	0.1669
Echinococcus multilocularis	somatostatin receptor	0.0038	0.1337	0.1669
Echinococcus granulosus	serotonin receptor	0.0038	0.1337	0.1669
Onchocerca volvulus		0.0038	0.1337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.1337	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.1337	1
Onchocerca volvulus		0.0038	0.1337	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Schistosoma mansoni	opsin-like receptor	0.0038	0.1337	0.1337
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.1337	0.1669
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.1337	0.1337
Schistosoma mansoni	adenoreceptor	0.0038	0.1337	0.1337
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.1337	0.1337
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.1337	0.1669
Echinococcus granulosus	g protein coupled receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Onchocerca volvulus		0.0038	0.1337	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.1337	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.1337	0.1337
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.1337	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.1337	0.1669
Brugia malayi	Dopamine receptor protein 1	0.0038	0.1337	1
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.1337	0.1669
Echinococcus granulosus	neuropeptide receptor	0.0038	0.1337	0.1669
Schistosoma mansoni	amine GPCR	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.1337	0.1669
Echinococcus granulosus	glutamate receptor NMDA	0.0095	0.7112	0.8879
Onchocerca volvulus		0.0038	0.1337	0.5
Onchocerca volvulus		0.0038	0.1337	0.5
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0461	0.0575
Onchocerca volvulus		0.0038	0.1337	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.1337	0.1669
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.1337	0.1669
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.1337	0.1669
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.1337	0.1669
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.1337	0.1669
Schistosoma mansoni	histamine h1 receptor	0.0038	0.1337	0.1337
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.1337	0.1669
Echinococcus granulosus	nmda type glutamate receptor	0.01	0.7572	0.9453
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.1337	0.1669
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.1337	0.1337
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.1337	0.1337
Echinococcus granulosus	allatostatin A receptor	0.0038	0.1337	0.1669
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.1337	0.1669
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	amine GPCR	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.1337	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.1337	0.1337
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.1337	0.1669
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.1337	1
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.1337	1
Schistosoma mansoni	hypothetical protein	0.0038	0.1337	0.1337
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0461	0.0575
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.1337	0.1669
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.1337	1
Brugia malayi	Melatonin receptor type 1A	0.0038	0.1337	1
Echinococcus multilocularis	nmda type glutamate receptor	0.0104	0.801	1
Echinococcus multilocularis	glutamate receptor 2	0.0029	0.0461	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.1337	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0461	0.0575
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.1337	0.1337
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.1337	0.1669
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.1337	0.1337
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.1337	0.1669
Schistosoma mansoni	biogenic amine receptor	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	neuropeptide receptor	0.0038	0.1337	0.1337
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.1337	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.1337	0.1669
Brugia malayi	Dopamine receptor protein 2	0.0038	0.1337	1
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.1337	1
Brugia malayi	Serotonin receptor	0.0038	0.1337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.1337	0.1337
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.1337	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.1337	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	neuropeptide receptor	0.0038	0.1337	0.1337
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.1337	0.1337
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.1337	1
Echinococcus granulosus	neuropeptide receptor	0.0038	0.1337	0.1669
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Brugia malayi	ORL1-like opioid receptor	0.0038	0.1337	1
Brugia malayi	neuropeptide F receptor	0.0038	0.1337	1
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.1337	0.1669
Brugia malayi	AKH receptor	0.0038	0.1337	1
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0029	0.0461	0.0575
Echinococcus granulosus	glutamate receptor 2	0.0029	0.0461	0.0575
Brugia malayi	hypothetical protein	0.0038	0.1337	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1337	1
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.1337	0.1669
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.1337	0.1337
Brugia malayi	neuropeptide F receptor	0.0038	0.1337	1
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.1337	0.1669
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.1337	0.1669

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1.6 nM	Displacement of [3H]-ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cells	ChEMBL.	12639560
Ki (binding)	= 1.6 nM	Displacement of [3H]-ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cells	ChEMBL.	12639560

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 20706466

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 276405