Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.5096 | 0.4103 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0412 | 1 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0394 | 0.9342 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0412 | 1 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0412 | 1 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0412 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0299 | 0.5902 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0412 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0136 | 0 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0412 | 1 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0224 | 0.3184 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0412 | 1 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0299 | 0.5902 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0412 | 1 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0371 | 0.85 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0371 | 0.85 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0412 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0136 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.5096 | 0.4103 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0299 | 0.5902 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0371 | 0.85 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0371 | 0.85 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0136 | 0 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0412 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0371 | 0.85 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0136 | 0 | 0.5 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0412 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 316 nM | Inhibitory concentration of the compound was evaluated against P2X purinoceptor 7 | ChEMBL. | 10762053 |
IC50 (binding) | = 316 nM | Inhibitory concentration of the compound was evaluated against P2X purinoceptor 7 | ChEMBL. | 10762053 |
Inhibition (functional) | = 17.63 % | Inhibition of ATP-stimulated [Ca2+] influx into macrophages loaded with fluorescent indicator fura-2-acetoxymethyl at 50 nM concentration of compound | ChEMBL. | 10762053 |
Inhibition (functional) | = 58.8 % | Inhibition of ATP-stimulated [Ca2+] influx into macrophages loaded with fluorescent indicator fura-2-acetoxymethyl at 500 nM concentration of compound | ChEMBL. | 10762053 |
Inhibition (functional) | = 58.8 % | Inhibition of ATP-stimulated [Ca2+] influx into macrophages loaded with fluorescent indicator fura-2-acetoxymethyl at 1000 nM concentration of compound | ChEMBL. | 10762053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.