Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Schistosoma japonicum | ko:K04165 Oamb gene product from transcript, putative | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0319 | 0.6296 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0319 | 0.6296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.7306 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0319 | 0.6296 | 1 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0363 | 0.7306 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.7306 | 1 |
Onchocerca volvulus | 0.007 | 0.0551 | 1 | |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.007 | 0.0551 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0118 | 0.1647 | 0.5 |
Echinococcus multilocularis | folate receptor beta | 0.048 | 1 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0363 | 0.7306 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -6.25 | Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor | ChEMBL. | 11262079 |
IC50 (binding) | = -6.08 | Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor | ChEMBL. | 11262079 |
Log IC50 (binding) | = 6.08 | Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptor | ChEMBL. | 11262079 |
Log IC50 (binding) | = 6.25 | Binding affinity in CHO-K1 cells transfected with human 5-hydroxytryptamine 1D receptor | ChEMBL. | 11262079 |
pA2 (functional) | = 6.02 | Relative binding affinity in rabbit saphenous vein functional assay compared to 5-HT | ChEMBL. | 11262079 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.