Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.1109 | 0.3742 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0245 | 0.0204 | 0.5 |
Echinococcus multilocularis | folate receptor beta | 0.2638 | 1 | 0.5 |
Onchocerca volvulus | 0.0245 | 0.0204 | 1 | |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.1109 | 0.3742 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0648 | 0.1856 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.1109 | 0.3742 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k (ADMET) | = 0.857 hr-1 | Hydrolysis rate constant of the compound at pH 10 | ChEMBL. | 6716407 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.