Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Phospholipase A2 homolog | 0.1139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1139 | 0.5 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.1139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1139 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 43 % | Percent inhibition LTD4-induced contraction of guinea pig ileum at 30 uM of concentration | ChEMBL. | 3031291 |
pKB (functional) | Inhibition of LTD4-induced contraction of guinea pig ileum; No data. | ChEMBL. | 3031291 | |
pKB (functional) | 0 | Inhibition of LTD4-induced contraction of guinea pig ileum; No data. | ChEMBL. | 3031291 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.