Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0595 | 0.4244 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0595 | 0.4244 | 1 |
Toxoplasma gondii | hypothetical protein | 0.031 | 0.1776 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0131 | 0.0231 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0595 | 0.4244 | 1 |
Echinococcus multilocularis | folate receptor beta | 0.126 | 1 | 0.5 |
Onchocerca volvulus | 0.0131 | 0.0231 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/C (ADMET) | = 6.03 | log(1/C) was estimated in mice | ChEMBL. | 2918519 |
logP (ADMET) | = -0.21 | Partition coefficient (logP) | ChEMBL. | 2918519 |
MED (functional) | = 0.000000932 M kg-1 | Minimum effective dose was determined on P388 leukemia cells in mice | ChEMBL. | 2918519 |
MED (functional) | = 0.000000932 M kg-1 | Minimum effective dose was determined on P388 leukemia cells in mice | ChEMBL. | 2918519 |
MED (functional) | = 0.4 mg kg-1 | Minimum effective dose was determined on P388 leukemia cells in mice | ChEMBL. | 2918519 |
MED (functional) | = 0.4 mg kg-1 | Minimum effective dose was determined on P388 leukemia cells in mice | ChEMBL. | 2918519 |
T/C (functional) | = 150 % | Maximal effect of the given optimal dose of 12.8 mg/kg of the compound against P388 leukemia cells in mice | ChEMBL. | 2918519 |
T/C (functional) | = 150 % | Maximal effect of the given optimal dose of 12.8 mg/kg of the compound against P388 leukemia cells in mice | ChEMBL. | 2918519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.