Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | squalene synthase, putative | 1.1151 | 0.5 | 0.5 |
Trypanosoma brucei | squalene synthase, putative | 1.1151 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 1.1151 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP decrease (functional) | = 37.3 % | Percentage blood pressure lowering in spontaneously hypertensive rats within 3 h of intraperitoneal administration of the compound at 2 mg/kg | ChEMBL. | 7401100 |
MED (functional) | = 0.04 mg kg-1 | Minimum effective dose level to give significant blood pressure lowering effect in normotensive rabbits after administering intravenously | ChEMBL. | 7401100 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.