Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0365 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0952 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0952 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0952 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0952 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0952 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0952 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0365 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0952 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0952 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0952 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 41.4 nM | Inhibitory activity against dopamine transporter (DAT) labeled with [3H]-WIN- 35,428 in rat brain striatal membrane. | ChEMBL. | 9513598 |
IC50 (binding) | = 271.2 nM | Inhibitory activity against serotonin transporter (SERT) labeled with [3H]-citalopram in rat brain striatal membrane. | ChEMBL. | 9513598 |
Ratio (binding) | = 6.5 | Ratio between the IC50 values of SERT and DAT | ChEMBL. | 9513598 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.