Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0067 | 0.2497 | 0.5 | |
Echinococcus granulosus | Ankyrin | 0.0015 | 0.0006 | 0.0006 |
Brugia malayi | bZIP transcription factor family protein | 0.0085 | 0.337 | 1 |
Echinococcus granulosus | jun protein | 0.0085 | 0.337 | 0.337 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.3258 | 1 |
Echinococcus multilocularis | jun protein | 0.0085 | 0.337 | 0.337 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0085 | 0.337 | 0.337 |
Schistosoma mansoni | jun-related protein | 0.0069 | 0.2608 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0085 | 0.337 | 0.337 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.2608 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0224 | 1 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0015 | 0.0006 | 0.0006 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0015 | 0.0006 | 0.0023 |
Brugia malayi | hypothetical protein | 0.0067 | 0.2497 | 0.7409 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logD | = -0.52 | Partition coefficient between 1-octanol and water containing phosphate buffer at pH 7.4 | ChEMBL. | 6425501 |
MED (functional) | = 0.2 mg kg-1 | Minimum effective dose against P388 leukemic cells | ChEMBL. | 6425501 |
MED (functional) | = 0.2 mg kg-1 | Minimum effective dose against P388 leukemic cells | ChEMBL. | 6425501 |
OD (functional) | = 25.6 mg kg-1 | Optimum dose (mg/kg) against P388 leukemic cells | ChEMBL. | 6425501 |
OD (functional) | = 25.6 mg kg-1 | Optimum dose (mg/kg) against P388 leukemic cells | ChEMBL. | 6425501 |
T/C (functional) | = 213 % | Maximum percent T/C (antitumor activity) against P388 leukemia cells for Mitomycin C | ChEMBL. | 6425501 |
T/C (functional) | = 213 % | Maximum percent T/C (antitumor activity) against P388 leukemia cells for Mitomycin C | ChEMBL. | 6425501 |
T/C (functional) | = 225 % | Maximum percent T/C (antitumor activity) against P388 leukemia cells | ChEMBL. | 6425501 |
T/C (functional) | = 225 % | Maximum percent T/C (antitumor activity) against P388 leukemia cells | ChEMBL. | 6425501 |
Therapeutic ratio (functional) | = 128 | Ratio of optimal dose (OD) and minimum effective dose (MED) required for antitumor activity in mice bearing P-388 lymphocytic leukemia | ChEMBL. | 6425501 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.