TDR Targets

Basic information

Technical information

TDR Targets ID: 279827
Name: 4,6-dichloro-3-[(3-cyclohexyl-2,4-dioxoimidaz olidin-1-yl)methyl]-1H-indole-2-carboxylic ac id
MW: 424.278 | Formula: C19H19Cl2N3O4
H donors: 2 H acceptors: 4 LogP: 3.87 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc(Cl)c2c(c1)[nH]c(c2CN1CC(=O)N(C1=O)C1CCCCC1)C(=O)O
InChi: 1S/C19H19Cl2N3O4/c20-10-6-13(21)16-12(17(18(26)27)22-14(16)7-10)8-23-9-15(25)24(19(23)28)11-4-2-1-3-5-11/h6-7,11,22H,1-5,8-9H2,(H,26,27)
InChiKey: MVNKLJDCEVKDQP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4,6-dichloro-3-[(3-cyclohexyl-2,4-dioxo-imidazolidin-1-yl)methyl]-1H-indole-2-carboxylic acid
4,6-dichloro-3-[(3-cyclohexyl-2,4-dioxo-1-imidazolidinyl)methyl]-1H-indole-2-carboxylic acid
4,6-dichloro-3-[(3-cyclohexyl-2,4-diketo-imidazolidin-1-yl)methyl]-1H-indole-2-carboxylic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, ionotropic, N-methyl D-aspartate 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma mansoni	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	glutamate receptor NMDA	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus multilocularis	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	Glutamate [NMDA] receptor subunit zeta-1 precursor, putative	Get druggable targets OG5_133478	All targets in OG5_133478
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133478	All targets in OG5_133478
Echinococcus granulosus	nmda type glutamate receptor	Get druggable targets OG5_133478	All targets in OG5_133478

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus granulosus	g protein coupled receptor	0.012	0.9641	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.9641	1
Brugia malayi	neuropeptide F receptor	0.012	0.9641	1
Brugia malayi	Serotonin receptor	0.012	0.9641	1
Echinococcus granulosus	g protein coupled receptor	0.012	0.9641	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.9641	0.9641
Echinococcus granulosus	neuropeptides capa receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Brugia malayi	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.012	0.9641	1
Echinococcus granulosus	neuropeptide receptor A26	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Brugia malayi	Dopamine receptor protein 1	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Brugia malayi	G protein-coupled receptor	0.012	0.9641	1
Schistosoma mansoni	biogenic amine receptor	0.012	0.9641	0.9641
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.012	0.9641	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.012	0.9641	1
Schistosoma mansoni	histamine h1 receptor	0.012	0.9641	0.9641
Onchocerca volvulus		0.012	0.9641	0.5
Brugia malayi	RE15519p	0.012	0.9641	1
Schistosoma mansoni	biogenic amine receptor	0.012	0.9641	0.9641
Brugia malayi	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0461	0.0478
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.012	0.9641	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.9641	0.9641
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	neuropeptide receptor	0.012	0.9641	0.9641
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.9641	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.012	0.9641	1
Echinococcus multilocularis	neuropeptides capa receptor	0.012	0.9641	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.9641	0.9641
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Brugia malayi	larval opioid receptor	0.012	0.9641	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.012	0.9641	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.012	0.9641	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.012	0.9641	0.9641
Echinococcus granulosus	sex peptide receptor	0.012	0.9641	1
Brugia malayi	hypothetical protein	0.012	0.9641	1
Brugia malayi	Dopamine receptor protein 2	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus granulosus	glutamate receptor 2	0.0029	0.0461	0.0478
Echinococcus multilocularis	neuropeptide FF receptor 2	0.012	0.9641	1
Loa Loa (eye worm)	TYRA-2 protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.012	0.9641	0.9641
Brugia malayi	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus granulosus	g-protein coupled receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	neuropeptide F-like receptor	0.012	0.9641	0.9641
Echinococcus multilocularis	neuropeptide Y receptor	0.012	0.9641	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.012	0.9641	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.012	0.9641	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.9641	1
Echinococcus multilocularis	allatostatin A receptor	0.012	0.9641	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.012	0.9641	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.012	0.9641	0.9641
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.012	0.9641	1
Schistosoma mansoni	hypothetical protein	0.012	0.9641	0.9641
Echinococcus granulosus	neuropeptide receptor	0.012	0.9641	1
Echinococcus granulosus	nmda type glutamate receptor	0.01	0.7572	0.7855
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.012	0.9641	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0461	0.0478
Echinococcus granulosus	tm gpcr rhodopsin	0.012	0.9641	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.012	0.9641	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.012	0.9641	0.9641
Brugia malayi	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.012	0.9641	1
Schistosoma mansoni	hypothetical protein	0.012	0.9641	0.9641
Brugia malayi	AKH receptor	0.012	0.9641	1
Echinococcus multilocularis	glutamate receptor 2	0.0029	0.0461	0.0478
Brugia malayi	hypothetical protein	0.012	0.9641	1
Brugia malayi	Dopamine receptor	0.012	0.9641	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.012	0.9641	1
Loa Loa (eye worm)	G-protein coupled receptor	0.012	0.9641	1
Schistosoma mansoni	neuropeptide F-like receptor	0.012	0.9641	0.9641
Schistosoma mansoni	biogenic amine receptor	0.012	0.9641	0.9641
Echinococcus granulosus	biogenic amine 5HT receptor	0.012	0.9641	1
Echinococcus multilocularis	g-protein coupled receptor	0.012	0.9641	1
Echinococcus multilocularis	serotonin receptor	0.012	0.9641	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.9641	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0461	0.0478
Schistosoma mansoni	opsin-like receptor	0.012	0.9641	0.9641
Loa Loa (eye worm)	G-protein coupled receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus granulosus	G protein coupled receptor 139	0.012	0.9641	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.012	0.9641	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.012	0.9641	1
Echinococcus multilocularis	glutamate receptor NMDA	0.0095	0.7112	0.7377
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.012	0.9641	0.9641
Schistosoma mansoni	neuropeptide receptor	0.012	0.9641	0.9641
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.9641	0.9641
Onchocerca volvulus		0.012	0.9641	0.5
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus granulosus	g protein coupled receptor	0.012	0.9641	1
Schistosoma mansoni	hypothetical protein	0.012	0.9641	0.9641
Brugia malayi	G protein-coupled receptor F59B2.13	0.012	0.9641	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.012	0.9641	1
Echinococcus multilocularis	sex peptide receptor	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.012	0.9641	1
Echinococcus granulosus	somatostatin receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	nmda type glutamate receptor	0.01	0.7572	0.7855
Schistosoma mansoni	opsin-like receptor	0.012	0.9641	0.9641
Brugia malayi	putative neuropeptide receptor NPR1	0.012	0.9641	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.9641	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.012	0.9641	0.9641
Brugia malayi	Melatonin receptor type 1A	0.012	0.9641	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.012	0.9641	0.9641
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.012	0.9641	1
Brugia malayi	hypothetical protein	0.012	0.9641	1
Brugia malayi	Serotonin receptor	0.012	0.9641	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.012	0.9641	0.9641
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus granulosus	allatostatin A receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus granulosus	fmrfamide receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.012	0.9641	1
Echinococcus granulosus	tm gpcr rhodopsin	0.012	0.9641	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0461	0.0478
Echinococcus multilocularis	neuropeptide receptor	0.012	0.9641	1
Schistosoma mansoni	amine GPCR	0.012	0.9641	0.9641
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.9641	1
Schistosoma mansoni	adenoreceptor	0.012	0.9641	0.9641
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.9641	0.9641
Echinococcus multilocularis	dro:myosuppressin receptor	0.012	0.9641	1
Echinococcus granulosus	neuropeptide receptor	0.012	0.9641	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.012	0.9641	1
Echinococcus multilocularis	G protein coupled receptor 139	0.012	0.9641	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.012	0.9641	1
Echinococcus multilocularis	somatostatin receptor	0.012	0.9641	1
Echinococcus granulosus	hypothetical protein	0.012	0.9641	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.012	0.9641	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.9641	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.9641	1
Echinococcus multilocularis	neuropeptide Y receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Brugia malayi	hypothetical protein	0.012	0.9641	1
Echinococcus granulosus	glutamate receptor NMDA	0.0095	0.7112	0.7377
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.012	0.9641	0.5
Echinococcus granulosus	serotonin receptor	0.012	0.9641	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.012	0.9641	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.9641	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0029	0.0461	0.0478
Schistosoma mansoni	alpha-1 adrenergic receptor	0.012	0.9641	0.9641
Brugia malayi	putative neuropeptide receptor	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus multilocularis	fmrfamide receptor	0.012	0.9641	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.9641	1
Echinococcus multilocularis	neuropeptides capa receptor	0.012	0.9641	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0461	0.0478
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.9641	1
Echinococcus multilocularis	g protein coupled receptor	0.012	0.9641	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.012	0.9641	0.9641
Echinococcus granulosus	neuropeptides capa receptor	0.012	0.9641	1
Brugia malayi	sulfakinin receptor protein	0.012	0.9641	1
Echinococcus multilocularis	g protein coupled receptor	0.012	0.9641	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.9641	0.9641
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	amine GPCR	0.012	0.9641	0.9641
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.012	0.9641	0.9641
Schistosoma mansoni	neuropeptide receptor	0.012	0.9641	0.9641
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.9641	0.9641
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	neuropeptide F receptor	0.012	0.9641	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.012	0.9641	0.9641
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.012	0.9641	1
Echinococcus multilocularis	neuropeptide receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.012	0.9641	0.9641
Schistosoma mansoni	myosin xvIII	0.012	0.9641	0.9641
Schistosoma mansoni	opsin-like receptor	0.012	0.9641	0.9641
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.9641	0.9641
Brugia malayi	Tachykinin-like peptides receptor 99D	0.012	0.9641	1
Brugia malayi	neuropeptide F receptor	0.012	0.9641	1
Echinococcus granulosus	dro:myosuppressin receptor	0.012	0.9641	1
Brugia malayi	G-protein coupled receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	fmrfamide receptor	0.012	0.9641	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.9641	0.9641
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.012	0.9641	0.9641
Echinococcus granulosus	nmda type glutamate receptor	0.0104	0.801	0.8309
Brugia malayi	GnHR receptor homolog	0.012	0.9641	1
Echinococcus granulosus	7tm_1 domain containing protein	0.012	0.9641	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	orexin receptor type 2	0.012	0.9641	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.012	0.9641	0.9641
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Brugia malayi	follicle stimulating hormone receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	amine GPCR	0.012	0.9641	0.9641
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus granulosus	orexin receptor type 2	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.9641	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	nmda type glutamate receptor	0.0104	0.801	0.8309
Brugia malayi	ORL1-like opioid receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Brugia malayi	hypothetical protein	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus multilocularis	serotonin receptor	0.012	0.9641	1
Brugia malayi	G-protein coupled receptor	0.012	0.9641	1
Echinococcus granulosus	neuropeptide Y receptor	0.012	0.9641	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.012	0.9641	0.9641
Echinococcus multilocularis	neuropeptide receptor A26	0.012	0.9641	1
Schistosoma mansoni	amine GPCR	0.012	0.9641	0.9641
Schistosoma mansoni	neuropeptide receptor	0.012	0.9641	0.9641
Onchocerca volvulus	Neuropeptide F receptor homolog	0.012	0.9641	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.012	0.9641	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.012	0.9641	1
Echinococcus multilocularis	g protein coupled receptor	0.012	0.9641	1
Schistosoma mansoni	amine GPCR	0.012	0.9641	0.9641
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.012	0.9641	0.9641
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.012	0.9641	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.012	0.9641	1
Schistosoma mansoni	hypothetical protein	0.012	0.9641	0.9641
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Echinococcus granulosus	neuropeptide s receptor	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.012	0.9641	1
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0029	0.0461	0.0478
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.012	0.9641	0.9641
Onchocerca volvulus		0.012	0.9641	0.5
Brugia malayi	hypothetical protein	0.012	0.9641	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0461	0.0478
Loa Loa (eye worm)	hypothetical protein	0.012	0.9641	1
Onchocerca volvulus		0.012	0.9641	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.012	0.9641	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.9641	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.13 uM	Tested for the affinity for the glycine binding site of the N-methyl-D-aspartate glutamate receptor using pig brain membranes in binding assay with [3H]-MDL- 105,519	ChEMBL.	12502360
Ki (binding)	= 0.13 uM	Tested for the affinity for the glycine binding site of the N-methyl-D-aspartate glutamate receptor using pig brain membranes in binding assay with [3H]-MDL- 105,519	ChEMBL.	12502360

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10938783

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 279827