Detailed information for compound 279867

Basic information

Technical information
  • TDR Targets ID: 279867
  • Name: 4,6-dichloro-3-[[3-(4-methylphenyl)-2,4-dioxo imidazolidin-1-yl]methyl]-1H-indole-2-carboxy lic acid
  • MW: 432.257 | Formula: C20H15Cl2N3O4
  • H donors: 2 H acceptors: 4 LogP: 3.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)N1C(=O)CN(C1=O)Cc1c([nH]c2c1c(Cl)cc(c2)Cl)C(=O)O
  • InChi: 1S/C20H15Cl2N3O4/c1-10-2-4-12(5-3-10)25-16(26)9-24(20(25)29)8-13-17-14(22)6-11(21)7-15(17)23-18(13)19(27)28/h2-7,23H,8-9H2,1H3,(H,27,28)
  • InChiKey: DHRVFYPUBAVXCQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4,6-dichloro-3-[[2,4-dioxo-3-(p-tolyl)imidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid
  • 4,6-dichloro-3-[[2,4-dioxo-3-(p-tolyl)-1-imidazolidinyl]methyl]-1H-indole-2-carboxylic acid
  • 4,6-dichloro-3-[[3-(4-methylphenyl)-2,4-dioxo-imidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid
  • 4,6-dichloro-3-[[2,4-diketo-3-(p-tolyl)imidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid
  • 4,6-dichloro-3-[[3-(4-methylphenyl)-2,4-dioxo-1-imidazolidinyl]methyl]-1H-indole-2-carboxylic acid
  • 4,6-dichloro-3-[[2,4-diketo-3-(4-methylphenyl)imidazolidin-1-yl]methyl]-1H-indole-2-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum expressed protein Get druggable targets OG5_133478 All targets in OG5_133478
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein coupled receptor 0.0059 0.349 0.4357
Onchocerca volvulus 0.0059 0.349 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0059 0.349 0.349
Brugia malayi sulfakinin receptor protein 0.0059 0.349 1
Brugia malayi AKH receptor 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Onchocerca volvulus 0.0059 0.349 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0461 0.0575
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0059 0.349 0.349
Schistosoma mansoni biogenic amine receptor 0.0059 0.349 0.349
Brugia malayi Melatonin receptor type 1A 0.0059 0.349 1
Onchocerca volvulus 0.0059 0.349 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.349 0.4357
Echinococcus multilocularis fmrfamide receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0059 0.349 0.4357
Echinococcus granulosus allatostatin A receptor 0.0059 0.349 0.4357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.349 0.349
Brugia malayi Tachykinin-like peptides receptor 99D 0.0059 0.349 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0059 0.349 0.4357
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.349 1
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0059 0.349 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0059 0.349 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0059 0.349 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0059 0.349 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.349 0.4357
Echinococcus granulosus glutamate receptor NMDA 0.0095 0.7112 0.8879
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.349 0.349
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.349 0.4357
Echinococcus granulosus nmda type glutamate receptor 0.01 0.7572 0.9453
Brugia malayi Dopamine receptor 0.0059 0.349 1
Brugia malayi neuropeptide F receptor 0.0059 0.349 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0059 0.349 0.349
Schistosoma mansoni biogenic amine receptor 0.0059 0.349 0.349
Echinococcus multilocularis serotonin receptor 0.0059 0.349 0.4357
Echinococcus granulosus g protein coupled receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.349 1
Brugia malayi hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Brugia malayi hypothetical protein 0.0059 0.349 1
Echinococcus granulosus neuropeptide s receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Onchocerca volvulus 0.0059 0.349 0.5
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0029 0.0461 0.0575
Onchocerca volvulus 0.0059 0.349 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0059 0.349 0.4357
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0059 0.349 0.4357
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.349 0.349
Onchocerca volvulus 0.0059 0.349 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0059 0.349 0.4357
Echinococcus multilocularis g protein coupled receptor 0.0059 0.349 0.4357
Brugia malayi hypothetical protein 0.0059 0.349 1
Echinococcus granulosus g-protein coupled receptor 0.0059 0.349 0.4357
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.349 0.4357
Schistosoma mansoni neuropeptide receptor 0.0059 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Onchocerca volvulus 0.0059 0.349 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.349 0.4357
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0059 0.349 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0059 0.349 0.4357
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0059 0.349 0.349
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.349 0.4357
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0029 0.0461 0.0575
Schistosoma mansoni amine GPCR 0.0059 0.349 0.349
Brugia malayi larval opioid receptor 0.0059 0.349 1
Echinococcus granulosus sex peptide receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) TYRA-2 protein 0.0059 0.349 1
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.349 0.4357
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0059 0.349 0.349
Echinococcus multilocularis nmda type glutamate receptor 0.01 0.7572 0.9453
Schistosoma mansoni amine GPCR 0.0059 0.349 0.349
Schistosoma mansoni opsin-like receptor 0.0059 0.349 0.349
Echinococcus granulosus orexin receptor type 2 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis serotonin receptor 0.0059 0.349 0.4357
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.349 1
Onchocerca volvulus 0.0059 0.349 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0059 0.349 0.349
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.349 0.4357
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0461 0.0575
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus granulosus serotonin receptor 0.0059 0.349 0.4357
Onchocerca volvulus 0.0059 0.349 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0059 0.349 0.349
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0059 0.349 0.349
Brugia malayi G protein-coupled receptor 0.0059 0.349 1
Brugia malayi hypothetical protein 0.0059 0.349 1
Echinococcus granulosus glutamate receptor 2 0.0029 0.0461 0.0575
Brugia malayi G protein-coupled receptor F59B2.13 0.0059 0.349 1
Schistosoma mansoni myosin xvIII 0.0059 0.349 0.349
Echinococcus multilocularis g protein coupled receptor 0.0059 0.349 0.4357
Brugia malayi putative neuropeptide receptor 0.0059 0.349 1
Schistosoma mansoni neuropeptide receptor 0.0059 0.349 0.349
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0059 0.349 0.4357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.349 0.4357
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0059 0.349 0.4357
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.349 0.4357
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Brugia malayi Serotonin receptor 0.0059 0.349 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.349 0.349
Brugia malayi Dopamine receptor protein 2 0.0059 0.349 1
Echinococcus multilocularis G protein coupled receptor 139 0.0059 0.349 0.4357
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.349 0.4357
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.349 1
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.349 0.4357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis nmda type glutamate receptor 0.0104 0.801 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0059 0.349 0.4357
Echinococcus granulosus nmda type glutamate receptor 0.0104 0.801 1
Onchocerca volvulus 0.0059 0.349 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.349 0.4357
Brugia malayi neuropeptide F receptor 0.0059 0.349 1
Brugia malayi ORL1-like opioid receptor 0.0059 0.349 1
Schistosoma mansoni neuropeptide receptor 0.0059 0.349 0.349
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.349 0.349
Brugia malayi Serotonin receptor 0.0059 0.349 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0059 0.349 0.349
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.349 0.4357
Schistosoma mansoni amine GPCR 0.0059 0.349 0.349
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.349 0.349
Schistosoma mansoni histamine h1 receptor 0.0059 0.349 0.349
Onchocerca volvulus 0.0059 0.349 0.5
Brugia malayi follicle stimulating hormone receptor 0.0059 0.349 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.349 0.349
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0461 0.0575
Echinococcus granulosus neuropeptide receptor 0.0059 0.349 0.4357
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.349 0.4357
Echinococcus granulosus hypothetical protein 0.0059 0.349 0.4357
Brugia malayi G-protein coupled receptor 0.0059 0.349 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0059 0.349 0.4357
Echinococcus multilocularis neuropeptide s receptor 0.0059 0.349 0.4357
Brugia malayi hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0461 0.0575
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0059 0.349 1
Echinococcus multilocularis somatostatin receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.349 0.4357
Echinococcus multilocularis G-protein coupled receptor, putative 0.0059 0.349 0.4357
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.349 0.4357
Schistosoma mansoni hypothetical protein 0.0059 0.349 0.349
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0059 0.349 0.4357
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0059 0.349 0.4357
Echinococcus granulosus g protein coupled receptor 0.0059 0.349 0.4357
Echinococcus granulosus neuropeptide receptor A26 0.0059 0.349 0.4357
Schistosoma mansoni adenoreceptor 0.0059 0.349 0.349
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.349 0.4357
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0461 0.0575
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0059 0.349 0.4357
Onchocerca volvulus 0.0059 0.349 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Brugia malayi GnHR receptor homolog 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis neuropeptide receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Onchocerca volvulus 0.0059 0.349 0.5
Echinococcus granulosus g protein coupled receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.349 0.4357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.349 0.4357
Schistosoma mansoni hypothetical protein 0.0059 0.349 0.349
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.349 0.4357
Echinococcus multilocularis sex peptide receptor 0.0059 0.349 0.4357
Schistosoma mansoni amine GPCR 0.0059 0.349 0.349
Echinococcus multilocularis neuropeptide receptor A26 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0059 0.349 0.4357
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.349 0.4357
Brugia malayi hypothetical protein 0.0059 0.349 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.349 0.349
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.349 0.349
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis glutamate receptor NMDA 0.0095 0.7112 0.8879
Echinococcus multilocularis orexin receptor type 2 0.0059 0.349 0.4357
Echinococcus multilocularis dro:myosuppressin receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus granulosus neuropeptide receptor 0.0059 0.349 0.4357
Onchocerca volvulus 0.0059 0.349 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Brugia malayi hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis fmrfamide receptor 0.0059 0.349 0.4357
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0059 0.349 0.349
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.349 0.349
Schistosoma mansoni opsin-like receptor 0.0059 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0059 0.349 1
Echinococcus granulosus dro:myosuppressin receptor 0.0059 0.349 0.4357
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.349 0.4357
Brugia malayi G-protein coupled receptor 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus granulosus somatostatin receptor 0.0059 0.349 0.4357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.349 0.349
Brugia malayi hypothetical protein 0.0059 0.349 1
Brugia malayi Dopamine receptor protein 1 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Schistosoma mansoni amine GPCR 0.0059 0.349 0.349
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.349 0.349
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0059 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Onchocerca volvulus 0.0059 0.349 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Schistosoma mansoni neuropeptide receptor 0.0059 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.349 0.4357
Schistosoma mansoni hypothetical protein 0.0059 0.349 0.349
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.349 0.4357
Echinococcus multilocularis allatostatin A receptor 0.0059 0.349 0.4357
Echinococcus granulosus fmrfamide receptor 0.0059 0.349 0.4357
Echinococcus multilocularis neuropeptide receptor 0.0059 0.349 0.4357
Echinococcus multilocularis g-protein coupled receptor 0.0059 0.349 0.4357
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0461 0.0575
Onchocerca volvulus 0.0059 0.349 0.5
Brugia malayi RE15519p 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.349 0.349
Echinococcus granulosus G protein coupled receptor 139 0.0059 0.349 0.4357
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0461 0.0575
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.349 0.4357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.349 0.4357
Brugia malayi hypothetical protein 0.0059 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.349 1
Onchocerca volvulus 0.0059 0.349 0.5
Brugia malayi hypothetical protein 0.0059 0.349 1
Schistosoma mansoni hypothetical protein 0.0059 0.349 0.349
Echinococcus granulosus alpha 1A adrenergic receptor 0.0059 0.349 0.4357
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.349 0.4357
Echinococcus multilocularis neuropeptide FF receptor 2 0.0059 0.349 0.4357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.349 0.4357
Schistosoma mansoni biogenic amine receptor 0.0059 0.349 0.349
Schistosoma mansoni opsin-like receptor 0.0059 0.349 0.349
Onchocerca volvulus Neuropeptide F receptor homolog 0.0059 0.349 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0059 0.349 0.4357
Echinococcus granulosus neuropeptide FF receptor 2 0.0059 0.349 0.4357
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0059 0.349 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.349 0.4357

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.036 uM Tested for the affinity for the glycine binding site of the N-methyl-D-aspartate glutamate receptor using pig brain membranes in binding assay with [3H]-MDL- 105,519 ChEMBL. 12502360
Ki (binding) = 0.036 uM Tested for the affinity for the glycine binding site of the N-methyl-D-aspartate glutamate receptor using pig brain membranes in binding assay with [3H]-MDL- 105,519 ChEMBL. 12502360

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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