Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.2728 | 0.1141 | 1 |
Onchocerca volvulus | 0.3554 | 1 | 0.5 | |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.2728 | 0.1141 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.2728 | 0.1141 | 0.1141 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.2728 | 0.1141 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3512 | 0.9553 | 0.9553 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2622 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2622 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2622 | 0 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.2728 | 0.1141 | 0.1141 |
Onchocerca volvulus | 0.3554 | 1 | 0.5 | |
Leishmania major | carbonic anhydrase-like protein | 0.2622 | 0 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.3554 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 % | In vitro agonist angiotensin II like activity was measured in the rabbit aorta strip assay | ChEMBL. | 3351849 |
BP increase (functional) | = 2.5 mmHg | In vivo agonist angiotensin II like activity was measured in rat blood pressure increase by a 1 ug iv injection | ChEMBL. | 3351849 |
ID50 (functional) | = 100 ng min-1 rat-1 | Antagonist activity ID50 was measured in vivo in the rat blood pressure assay | ChEMBL. | 3351849 |
pA2 (functional) | = 6.75 | In vitro antagonist activity against Angiotensin II receptor was measured in the rabbit aorta strip assay | ChEMBL. | 3351849 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.