Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0056 | 0.0056 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0086 | 0 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.0056 | 1 |
Trichomonas vaginalis | pten, drome, putative | 0.0086 | 0 | 0.5 |
Leishmania major | protein-tyrosine phosphatase 1-like protein | 0.0086 | 0 | 0.5 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0086 | 0 | 0.5 |
Onchocerca volvulus | 0.26 | 1 | 1 | |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1922 | 0.7303 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1922 | 0.7303 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1922 | 0.7303 | 1 |
Giardia lamblia | Protein tyrosine phosphatase | 0.0086 | 0 | 0.5 |
Onchocerca volvulus | 0.26 | 1 | 1 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.26 | 1 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1922 | 0.7303 | 0.7303 |
Leishmania major | tyrosine specific protein phosphatase, putative | 0.0086 | 0 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.1922 | 0.7303 | 0.7303 |
Trypanosoma cruzi | tyrosine specific protein phosphatase, putative | 0.0086 | 0 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.01 | 0.0056 | 1 |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0086 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 0.71 mM | 50% inhibition of human placental alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrate | ChEMBL. | 6808133 |
IC50 (binding) | = 0.71 mM | 50% inhibition of human placental alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrate | ChEMBL. | 6808133 |
Inhibition (functional) | 0 % | Percent inhibition of rat passive cutaneous anaphylaxis model after intravenous administration of the 0.5 mg/kg; IA is Inactive | ChEMBL. | 6808133 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.