TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 940.14 | Formula: C46H73N11O10
H donors: 11 H acceptors: 11 LogP: -0.17 Rotable bonds: 35
Rule of 5 violations (Lipinski): 4
SMILES: CNCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(CC)C)C(=O)O)Cc1c[nH]cn1)C(CC)C)Cc1ccc(cc1)O)C(C)C)CCCCN
InChi: 1S/C46H73N11O10/c1-8-27(5)38(44(64)53-34(22-30-23-49-25-50-30)45(65)57-20-12-14-35(57)42(62)56-39(46(66)67)28(6)9-2)55-41(61)33(21-29-15-17-31(58)18-16-29)52-43(63)37(26(3)4)54-40(60)32(13-10-11-19-47)51-36(59)24-48-7/h15-18,23,25-28,32-35,37-39,48,58H,8-14,19-22,24,47H2,1-7H3,(H,49,50)(H,51,59)(H,52,63)(H,53,64)(H,54,60)(H,55,61)(H,56,62)(H,66,67)
InChiKey: JJRDETKDQBHEMI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Serotonin receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0006	0.0006
Echinococcus granulosus	G protein coupled receptor 139	0.0006	0.0006	0.0004
Echinococcus multilocularis	neuropeptides capa receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	sex peptide receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	g-protein coupled receptor	0.0006	0.0006	0.0004
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	g protein coupled receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	g protein coupled receptor	0.0006	0.0006	0.0004
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0006	0.0006	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0006	0.0006	0.0006
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0006	0.0006	0.0004
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus granulosus	neuropeptides capa receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	g-protein coupled receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.001	0.0056	0.0055
Onchocerca volvulus		0.0006	0.0006	1
Echinococcus granulosus	neuropeptide receptor A26	0.0006	0.0006	0.0004
Echinococcus multilocularis	fmrfamide receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0006	0.0006
Echinococcus granulosus	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.001	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0564	0.0563
Echinococcus multilocularis	cyclin dependent kinase 5	0.0048	0.0571	0.057
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	Tyrosine-protein kinase abl-1	0.001	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0006	0.0006	0.0006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Abl	0.001	0.0056	0.0055
Schistosoma mansoni	tyrosine kinase	0.001	0.0056	0.0056
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0006	0.0006	0.0006
Brugia malayi	SRC-1	0.0042	0.0489	0.0488
Echinococcus granulosus	g protein coupled receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	cyclin dependent kinase 1	0.0048	0.0571	0.057
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0048	0.0571	0.057
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	amine GPCR	0.0006	0.0006	0.0006
Brugia malayi	putative neuropeptide receptor NPR1	0.0006	0.0006	0.0004
Brugia malayi	Sex muscle abnormal protein 5	0.0008	0.004	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	follicle stimulating hormone receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0489	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	fmrfamide receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	neuropeptide Y receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0008	0.004	0.004
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0042	0.0489	0.0488
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0008	0.004	0.0039
Schistosoma mansoni	hypothetical protein	0.0006	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0042	0.0489	0.0488
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0038	0.0435	0.0434
Onchocerca volvulus		0.0006	0.0006	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	neuropeptide Y receptor	0.0006	0.0006	0.0004
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Onchocerca volvulus		0.0006	0.0006	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0048	0.0571	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0006	0.0006	0.0004
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0006	0.0006	0.0004
Schistosoma mansoni	growth factor receptor-bound protein	0.0008	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0006	0.0006	0.0004
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0006	0.0006	0.0004
Brugia malayi	AKH receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	c src tyrosine kinase	0.001	0.0056	0.0055
Giardia lamblia	Kinase, CMGC CDK	0.0048	0.0571	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0006	0.0006	0.0006
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0006	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus granulosus	biogenic amine 5HT receptor	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0048	0.0571	0.5
Schistosoma mansoni	hypothetical protein	0.0006	0.0006	0.0006
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0006	0.0006	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Loa Loa (eye worm)	TYRA-2 protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0571	0.057
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0006	0.0006	0.0004
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0435	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0571	0.0571
Schistosoma mansoni	neuropeptide F-like receptor	0.0006	0.0006	0.0006
Echinococcus multilocularis	g protein coupled receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Entamoeba histolytica	cell division protein kinase 2, putative	0.0048	0.0571	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0006	0.0006	0.0006
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0042	0.0489	0.0488
Schistosoma mansoni	tyrosine kinase	0.0005	0.0001	0.0001
Brugia malayi	larval opioid receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	cyclin dependent kinase	0.0048	0.0571	0.057
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0043	0.0496	0.0495
Echinococcus granulosus	neuropeptide receptor	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	orexin receptor type 2	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Schistosoma mansoni	tyrosine kinase	0.0005	0.0001	0.0001
Schistosoma mansoni	amine GPCR	0.0006	0.0006	0.0006
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0006	0.0006	0.0004
Echinococcus granulosus	tm gpcr rhodopsin	0.0006	0.0006	0.0004
Loa Loa (eye worm)	melatonin receptor type 1A	0.0006	0.0006	0.0004
Echinococcus granulosus	allatostatin A receptor	0.0006	0.0006	0.0004
Giardia lamblia	Kinase, CMGC CDK	0.0048	0.0571	0.5
Schistosoma mansoni	adenoreceptor	0.0006	0.0006	0.0006
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0761	1	1
Brugia malayi	Serotonin receptor	0.0006	0.0006	0.0004
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0048	0.0571	0.057
Loa Loa (eye worm)	G-protein coupled receptor	0.0006	0.0006	0.0004
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0006	0.0006	0.0004
Echinococcus granulosus	fmrfamide receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0042	0.0489	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus granulosus	serotonin receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Schistosoma mansoni	neuropeptide receptor	0.0006	0.0006	0.0006
Trypanosoma brucei	cdc2-related kinase 3	0.0048	0.0571	0.5
Schistosoma mansoni	tyrosine kinase	0.0042	0.0489	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0006	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Trypanosoma cruzi	cdc2-related kinase 1	0.0048	0.0571	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0006	0.0006	0.0004
Schistosoma mansoni	opsin-like receptor	0.0006	0.0006	0.0006
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0489	0.0488
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0042	0.0489	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	Variant SH3 domain containing protein	0.0008	0.004	0.0039
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Brugia malayi	G-protein coupled receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0006	0.0006	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0037	0.0419	0.0418
Brugia malayi	Dopamine receptor protein 1	0.0006	0.0006	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0006	0.0006
Schistosoma mansoni	neuropeptide receptor	0.0006	0.0006	0.0006
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0006	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	amine GPCR	0.0006	0.0006	0.0006
Echinococcus multilocularis	neuropeptide s receptor	0.0006	0.0006	0.0004
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0048	0.0571	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.001	0.0056	0.0055
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0038	0.0435	0.0434
Echinococcus multilocularis	neuropeptide receptor A26	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0034	0.0379	0.0378
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0006	0.0006
Echinococcus granulosus	sex peptide receptor	0.0006	0.0006	0.0004
Trypanosoma cruzi	cdc2-related kinase 1	0.0048	0.0571	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0006	0.0006
Plasmodium falciparum	protein kinase 5	0.0048	0.0571	0.5
Schistosoma mansoni	biogenic amine receptor	0.0006	0.0006	0.0006
Echinococcus multilocularis	allatostatin A receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	hypothetical protein	0.0006	0.0006	0.0006
Schistosoma mansoni	tyrosine kinase	0.0042	0.0489	0.0489
Plasmodium vivax	protein kinase Crk2	0.0048	0.0571	0.5
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0006	0.0006
Echinococcus multilocularis	neuropeptide Y receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0489	0.0488
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0042	0.0489	0.0488
Echinococcus multilocularis	serotonin receptor	0.0006	0.0006	0.0004
Brugia malayi	neuropeptide F receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	cyclin dependent kinase 1	0.0048	0.0571	0.057
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Echinococcus granulosus	orexin receptor type 2	0.0006	0.0006	0.0004
Echinococcus multilocularis	neuropeptide receptor	0.0006	0.0006	0.0004
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.0435	0.0434
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0006	0.0006	0.0004
Loa Loa (eye worm)	neuropeptide F receptor	0.0006	0.0006	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0042	0.0489	0.0488
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.0761	1	1
Entamoeba histolytica	protein kinase, putative	0.0034	0.0379	0.6626
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Loa Loa (eye worm)	TK protein kinase	0.0034	0.0379	0.0378
Schistosoma mansoni	biogenic amine receptor	0.0006	0.0006	0.0006
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0006	0.0006	0.0006
Brugia malayi	sulfakinin receptor protein	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0006	0.0006
Echinococcus granulosus	neuropeptide Y receptor	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0048	0.0571	1
Schistosoma mansoni	neuropeptide receptor	0.0006	0.0006	0.0006
Brugia malayi	neuropeptide F receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	opsin-like receptor	0.0006	0.0006	0.0006
Schistosoma mansoni	growth factor receptor-bound protein	0.0008	0.004	0.004
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0571	0.5
Echinococcus granulosus	somatostatin receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	tm gpcr rhodopsin	0.0006	0.0006	0.0004
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0048	0.0571	0.5
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0048	0.0571	0.057
Brugia malayi	GnHR receptor homolog	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0489	0.0488
Echinococcus granulosus	tm gpcr rhodopsin	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	protein-tyrosine kinase	0.0038	0.0435	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	NCK adaptor protein	0.0008	0.004	0.0039
Onchocerca volvulus		0.0006	0.0006	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	adapter molecule crk	0.0008	0.004	0.004
Echinococcus granulosus	tyrosine protein kinase Blk	0.0038	0.0435	0.0434
Brugia malayi	G protein-coupled receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	serotonin receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	nck2/grb4	0.0008	0.004	0.004
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0006	0.0006	0.0006
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0008	0.004	0.0039
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Echinococcus granulosus	biogenic amine 5HT receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	opsin-like receptor	0.0006	0.0006	0.0006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus granulosus	growth factor receptor bound protein 2	0.0008	0.004	0.0039
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0006	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0006	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0038	0.0435	0.0434
Schistosoma mansoni	neuropeptide receptor	0.0006	0.0006	0.0006
Echinococcus granulosus	g protein coupled receptor	0.0006	0.0006	0.0004
Trypanosoma brucei	cdc2-related kinase 1	0.0048	0.0571	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.0761	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0006	0.0006	0.0004
Schistosoma mansoni	amine GPCR	0.0006	0.0006	0.0006
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	biogenic amine receptor	0.0006	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0042	0.0489	0.0488
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0006	0.0006	0.0006
Echinococcus multilocularis	cyclin dependent kinase 1	0.0048	0.0571	0.057
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0006	0.0006	0.0006
Echinococcus granulosus	7TM GPCR rhodopsin	0.0006	0.0006	0.0004
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0006	0.0006	0.0004
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0006	0.0006	0.0006
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus granulosus	neuropeptide FF receptor 2	0.0006	0.0006	0.0004
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	Dopamine receptor protein 2	0.0006	0.0006	0.0004
Trypanosoma cruzi	cdc2-related kinase 3	0.0048	0.0571	0.5
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Loa Loa (eye worm)	SRC-1	0.0042	0.0489	0.0488
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0571	0.5
Brugia malayi	Dopamine receptor	0.0006	0.0006	0.0004
Schistosoma mansoni	amine GPCR	0.0006	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0008	0.004	0.0039
Schistosoma mansoni	neuropeptide F-like receptor	0.0006	0.0006	0.0006
Schistosoma mansoni	myosin xvIII	0.0006	0.0006	0.0006
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0042	0.0489	0.0488
Echinococcus multilocularis	g protein coupled receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0489	0.0488
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0006	0.0006	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.0761	1	1
Schistosoma mansoni	tyrosine kinase	0.001	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0006	0.0006	0.0004
Echinococcus multilocularis	somatostatin receptor	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	Melatonin receptor type 1A	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	RE15519p	0.0006	0.0006	0.0004
Schistosoma mansoni	neuropeptide f receptor 76f	0.0006	0.0006	0.0006
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0006	0.0006	0.0006
Echinococcus multilocularis	neuropeptides capa receptor	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0006	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0006	0.0006	0.0006
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	cyclin dependent kinase	0.0048	0.0571	0.057
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0006	0.0006	0.0006
Echinococcus granulosus	c src tyrosine kinase	0.001	0.0056	0.0055
Onchocerca volvulus		0.0006	0.0006	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Brugia malayi	Variant SH3 domain containing protein	0.0008	0.004	0.0039
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0571	0.0571
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0571	0.5
Echinococcus granulosus	NCK adaptor protein	0.0008	0.004	0.0039
Brugia malayi	putative neuropeptide receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0048	0.0571	0.057
Brugia malayi	cell division control protein 2 homolog	0.0048	0.0571	0.057
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0006	0.0006	0.0004
Brugia malayi	ORL1-like opioid receptor	0.0006	0.0006	0.0004
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0006	0.0006	0.0004
Echinococcus multilocularis	neuropeptide receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0489	0.0488
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0006	0.0006	0.0004
Brugia malayi	G protein-coupled receptor F59B2.13	0.0006	0.0006	0.0004
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0006	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Onchocerca volvulus		0.0006	0.0006	1
Schistosoma mansoni	histamine h1 receptor	0.0006	0.0006	0.0006
Onchocerca volvulus		0.0006	0.0006	1
Echinococcus granulosus	neuropeptide s receptor	0.0006	0.0006	0.0004
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0006	0.0006	1
Echinococcus granulosus	neuropeptide receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	G protein coupled receptor 139	0.0006	0.0006	0.0004
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0006	0.0006	0.0004
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0008	0.004	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Brugia malayi	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus granulosus	tyrosine kinase	0.0038	0.0435	0.0434
Echinococcus granulosus	cyclin dependent kinase 5	0.0048	0.0571	0.057
Onchocerca volvulus		0.0006	0.0006	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0006	0.0006	0.0004
Echinococcus granulosus	neuropeptides capa receptor	0.0006	0.0006	0.0004
Brugia malayi	G-protein coupled receptor	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0042	0.0489	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0006	0.0004
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0037	0.0419	0.0418
Echinococcus granulosus	7tm_1 domain containing protein	0.0006	0.0006	0.0004
Echinococcus granulosus	tyrosine protein kinase HCK	0.0034	0.0379	0.0378

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0 %	In vitro agonist angiotensin II like activity was measured in the rabbit aorta strip assay	ChEMBL.	3351849
BP increase (functional)	= 12.5 mmHg	In vivo agonist angiotensin II like activity was measured in rat blood pressure increase by a 1 ug iv injection	ChEMBL.	3351849
ID50 (functional)	= 50 ng min-1 rat-1	Antagonist activity ID50 was measured in vivo in the rat blood pressure assay	ChEMBL.	3351849
pA2 (functional)	= 7.75	In vitro antagonist activity against Angiotensin II receptor was measured in the rabbit aorta strip assay	ChEMBL.	3351849

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 372014

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 280303