Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.01 | 0.6606 | 0.6606 |
Brugia malayi | Protein kinase domain containing protein | 0.0075 | 0.4142 | 0.1803 |
Schistosoma mansoni | tyrosine kinase | 0.006 | 0.2748 | 0.0437 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0061 | 0.2854 | 0.0576 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0061 | 0.2854 | 0.2854 |
Schistosoma mansoni | tyrosine kinase | 0.006 | 0.2748 | 0.0437 |
Schistosoma mansoni | tyrosine kinase | 0.0061 | 0.2854 | 0.0576 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.4036 | 0.1655 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0061 | 0.2854 | 0.0576 |
Echinococcus granulosus | nmda type glutamate receptor | 0.01 | 0.6606 | 0.5524 |
Echinococcus multilocularis | insulin receptor | 0.0135 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0061 | 0.2854 | 0.0576 |
Schistosoma mansoni | tyrosine kinase | 0.0061 | 0.2854 | 0.0576 |
Schistosoma mansoni | tyrosine kinase | 0.0135 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0061 | 0.2854 | 0.0576 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0135 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0135 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.6158 | 0.6158 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0127 | 0.9268 | 0.9268 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0135 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0127 | 0.9268 | 0.9035 |
Echinococcus granulosus | insulin receptor | 0.0135 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0057 | 0.2417 | 0.2417 |
Schistosoma mansoni | tyrosine kinase | 0.006 | 0.2748 | 0.0437 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.6158 | 0.4934 |
Schistosoma mansoni | tyrosine kinase | 0.0135 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0109 | 0.7478 | 0.6675 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0061 | 0.2854 | 0.2854 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.58 uM | In vitro ability to displace [3H]L-689,560 binding to glycine site on the N-methyl-D-aspartate (NMDA) glutamate receptor 1 from rat cortical membranes | ChEMBL. | 9057862 |
IC50 (binding) | = 0.58 uM | In vitro ability to displace [3H]L-689,560 binding to glycine site on the N-methyl-D-aspartate (NMDA) glutamate receptor 1 from rat cortical membranes | ChEMBL. | 9057862 |
Kb (functional) | = 4.5 uM | Evaluated to antagonize NMDA responses in a rat cortical slice preparations | ChEMBL. | 9057862 |
Kb (functional) | = 4.5 uM | Evaluated to antagonize NMDA responses in a rat cortical slice preparations | ChEMBL. | 9057862 |
No. of mice protected (functional) | = 0 | Evaluated in vivo for their ability to protect against audiogenic seizure in DBA/2 mice when administered 20 mg/kg ip 30 min prior to noise stimulation out of 8 mice tested | ChEMBL. | 9057862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.