Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | neuropeptide F receptor | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.5289 | 0.5289 |
Brugia malayi | G-protein coupled receptor | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0059 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Brugia malayi | AKH receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.01 | 0.5967 | 0.5967 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.01 | 0.5967 | 0.5967 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.5289 | 0.5289 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0109 | 0.7289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Brugia malayi | Melatonin receptor type 1A | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0059 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0059 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0059 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 uM | Compound was evaluated for its binding affinity towards strychnine - insensitive glycine site of NMDA receptor in presence of [3H]- Gly | ChEMBL. | No reference |
IC50 (binding) | = 17 uM | Compound was evaluated for its binding affinity towards strychnine - insensitive glycine site of NMDA receptor in presence of [3H]- Gly | ChEMBL. | No reference |
IC50 (binding) | = 36 uM | Compound was evaluated for its binding affinity towards Ionotropic glutamate receptor AMPA in presence of [3H]- AMPA | ChEMBL. | No reference |
IC50 (binding) | = 36 uM | Compound was evaluated for its binding affinity towards Ionotropic glutamate receptor AMPA in presence of [3H]- AMPA | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Compound was evaluated for its binding affinity towards strychnine - insensitive glycine site of NMDA in presence of [3H]- CPP | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Compound was evaluated for its binding affinity towards strychnine - insensitive glycine site of NMDA in presence of [3H]- CPP | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.