Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0104 | 0.0786 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0104 | 0.0786 | 1 |
Brugia malayi | thymidylate synthase | 0.0104 | 0.0786 | 0.0786 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0104 | 0.0786 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0146 | 0.285 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0104 | 0.0786 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0293 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0104 | 0.0786 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0146 | 0.285 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0146 | 0.285 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0146 | 0.285 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0104 | 0.0786 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0146 | 0.285 | 0.5 |
Onchocerca volvulus | 0.0104 | 0.0786 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0104 | 0.0786 | 0.0786 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0146 | 0.285 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | % | In vivo reduction in serum estradiol in PMSG-primed rats after 6 hr at 5 mg/kg oral dose; Not determined | ChEMBL. | 8576919 |
Control (functional) | % | In vivo reduction in serum estradiol in PMSG-primed rats after 2 hr at 5 mg/kg oral dose; Not determined | ChEMBL. | 8576919 |
Control (functional) | 0 % | In vivo reduction in serum estradiol in PMSG-primed rats after 2 hr at 5 mg/kg oral dose; Not determined | ChEMBL. | 8576919 |
Control (functional) | 0 % | In vivo reduction in serum estradiol in PMSG-primed rats after 6 hr at 5 mg/kg oral dose; Not determined | ChEMBL. | 8576919 |
IC50 (binding) | = 0.0000074 M | In vitro inhibition to cytochrome P450 19A1 assayed using human placental microsomes | ChEMBL. | 8576919 |
IC50 (binding) | = 0.0000074 M | In vitro inhibition to cytochrome P450 19A1 assayed using human placental microsomes | ChEMBL. | 8576919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.