Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0132 | 0.1403 | 0.0963 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Schistosoma mansoni | serine-rich repeat protein | 0.0084 | 0.058 | 0.0096 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0358 | 0.5265 | 0.5265 |
Echinococcus multilocularis | peroxidasin | 0.0163 | 0.1927 | 0.1927 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0308 | 0.4419 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0084 | 0.0583 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0084 | 0.0583 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1403 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0074 | 0.0074 |
Schistosoma mansoni | amine GPCR | 0.0343 | 0.5013 | 0.4757 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.6756 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0132 | 0.1403 | 0.1403 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0163 | 0.1926 | 0.1926 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1403 | 0.1403 |
Brugia malayi | Peroxidasin | 0.0163 | 0.1927 | 0.2433 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0634 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0358 | 0.5265 | 0.5265 |
Echinococcus granulosus | peroxidasin | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0163 | 0.1926 | 0.1926 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0374 | 0.0374 |
Brugia malayi | Telomerase reverse transcriptase | 0.0224 | 0.2977 | 0.4079 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Echinococcus multilocularis | serotonin receptor | 0.0132 | 0.1403 | 0.1403 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.1927 | 0.1927 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0156 | 0.1813 | 0.1393 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.1927 | 0.1927 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.6756 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.3607 | 0.3607 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.6756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.4117 | 0.4117 |
Schistosoma mansoni | peroxidasin | 0.0163 | 0.1927 | 0.1513 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.6756 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0132 | 0.1403 | 0.1403 |
Giardia lamblia | Telomerase catalytic subunit | 0.0084 | 0.0583 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0634 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0634 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0163 | 0.1927 | 0.2433 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.058 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0084 | 0.0583 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0163 | 0.1927 | 0.2433 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.1927 | 0.1927 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0551 | 0.8583 | 0.851 |
Schistosoma mansoni | peroxidasin | 0.0163 | 0.1927 | 0.1513 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AD50 (functional) | = 17 mg kg-1 | Anticocaine activity was assessed through attenuation of convulsions caused by the intraperitoneal administration of cocaine 60 mg/kg in mice | ChEMBL. | 12639573 |
AD50 (functional) | = 17 mg kg-1 | Anticocaine activity was assessed through attenuation of convulsions caused by the intraperitoneal administration of cocaine 60 mg/kg in mice | ChEMBL. | 12639573 |
Ki (binding) | = 0.39 nM | Binding affinity towards Sigma-1 receptor | ChEMBL. | 12639573 |
Ki (binding) | = 0.39 nM | Binding affinity towards Sigma-1 receptor | ChEMBL. | 12639573 |
Ki (binding) | = 107.8 nM | Binding affinity towards Sigma-2 receptor | ChEMBL. | 12639573 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.