Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0221 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0221 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0221 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0221 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0221 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0221 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0221 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0221 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0221 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0221 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0221 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0221 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0221 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0221 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0221 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
30 day survival / total (functional) | = 0 | In vivo evaluation of 30 day survival against P388 lymphocytic leukemia in CD2F1 male mice at dose 40 mg/kg; out of 6 mice | ChEMBL. | 6204051 |
30 day survival / total (functional) | = 0 | In vivo evaluation of 30 day survival against P388 lymphocytic leukemia in CD2F1 male mice at dose 30 mg/kg; out of 6 mice | ChEMBL. | 6204051 |
ILS (functional) | = 41 % | In vivo evaluation of percent increase in life span (ILS) against P388 lymphocytic leukemia in infected CD2F1 male mice and at 30 dose mg/kg | ChEMBL. | 6204051 |
ILS (functional) | = 41 % | In vivo evaluation of percent increase in life span (ILS) against P388 lymphocytic leukemia in infected CD2F1 male mice and at 30 dose mg/kg | ChEMBL. | 6204051 |
ILS (functional) | = 88 % | In vivo evaluation of percent increase in life span (ILS) against P388 lymphocytic leukemia in infected CD2F1 male mice and at 40 dose mg/kg | ChEMBL. | 6204051 |
ILS (functional) | = 88 % | In vivo evaluation of percent increase in life span (ILS) against P388 lymphocytic leukemia in infected CD2F1 male mice and at 40 dose mg/kg | ChEMBL. | 6204051 |
Test/control survival (functional) | 0 day | In vivo evaluation of test/control survival against P388 lymphocytic leukemia in CD2F1 male mice at dose 40 mg/kg; 17.3 / 9.2 | ChEMBL. | 6204051 |
Test/control survival (functional) | 0 day | In vivo evaluation of test/control survival against P388 lymphocytic leukemia in CD2F1 male mice at dose 30 mg/kg; 13 / 9.2 | ChEMBL. | 6204051 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.