Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0307 | 0.2247 | 0.2247 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0307 | 0.2247 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0302 | 0.2168 | 0.8453 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0307 | 0.2247 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0307 | 0.2247 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0302 | 0.2168 | 0.9648 |
Echinococcus granulosus | dual specificity | 0.0276 | 0.1736 | 0.1736 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0307 | 0.2247 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0307 | 0.2247 | 0.2247 |
Trichomonas vaginalis | cyclin B, putative | 0.0302 | 0.2168 | 0.9648 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0302 | 0.2168 | 0.8453 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.166 | 0.166 |
Trichomonas vaginalis | cyclin B, putative | 0.0302 | 0.2168 | 0.9648 |
Brugia malayi | cell division control protein 2 homolog | 0.0307 | 0.2247 | 0.6723 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0307 | 0.2247 | 1 |
Brugia malayi | hypothetical protein | 0.0374 | 0.3343 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0302 | 0.2168 | 0.8453 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0307 | 0.2247 | 0.2247 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0781 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0307 | 0.2247 | 0.2247 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0276 | 0.1736 | 0.1736 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0307 | 0.2247 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0307 | 0.2247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.3343 | 0.3343 |
Echinococcus multilocularis | dual specificity | 0.0276 | 0.1736 | 0.1736 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0307 | 0.2247 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0302 | 0.2168 | 0.6486 |
Trichomonas vaginalis | cyclins, putative | 0.0302 | 0.2168 | 0.9648 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0307 | 0.2247 | 1 |
Onchocerca volvulus | 0.0302 | 0.2168 | 0.5 | |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0302 | 0.2168 | 0.8453 |
Trichomonas vaginalis | cyclins, putative | 0.0302 | 0.2168 | 0.9648 |
Trichomonas vaginalis | cyclins, putative | 0.0174 | 0.0066 | 0.0294 |
Entamoeba histolytica | protein kinase, putative | 0.0276 | 0.1736 | 0.7726 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0307 | 0.2247 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0302 | 0.2168 | 0.9648 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0307 | 0.2247 | 0.2247 |
Trypanosoma cruzi | cyclin 6, putative | 0.0302 | 0.2168 | 0.8453 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0307 | 0.2247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.166 | 0.166 |
Trichomonas vaginalis | cyclin B, putative | 0.0302 | 0.2168 | 0.9648 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.3343 | 0.3343 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0302 | 0.2168 | 0.6486 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0781 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0307 | 0.2247 | 0.2247 |
Brugia malayi | Protein kinase domain containing protein | 0.0307 | 0.2247 | 0.6723 |
Schistosoma mansoni | cyclin B | 0.0302 | 0.2168 | 0.2168 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0302 | 0.2168 | 0.9648 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2168 | 0.2168 |
Brugia malayi | Protein kinase domain containing protein | 0.0276 | 0.1736 | 0.5194 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0307 | 0.2247 | 0.2247 |
Echinococcus granulosus | cyclin dependent kinase | 0.0307 | 0.2247 | 0.2247 |
Entamoeba histolytica | protein kinase, putative | 0.0276 | 0.1736 | 0.7726 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2171 | 0.2171 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2168 | 0.2168 |
Trichomonas vaginalis | cyclins, putative | 0.0302 | 0.2168 | 0.9648 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0307 | 0.2247 | 0.2247 |
Trichomonas vaginalis | cyclins, putative | 0.0302 | 0.2168 | 0.9648 |
Giardia lamblia | Kinase, CMGC CDK | 0.0307 | 0.2247 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0302 | 0.2168 | 0.9648 |
Echinococcus granulosus | cyclin B | 0.0302 | 0.2168 | 0.2168 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0307 | 0.2247 | 0.2247 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0307 | 0.2247 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0307 | 0.2247 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0781 | 1 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0307 | 0.2247 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0302 | 0.2168 | 0.8453 |
Giardia lamblia | Kinase, CMGC CDK | 0.0307 | 0.2247 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0276 | 0.1736 | 0.7726 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0307 | 0.2247 | 1 |
Echinococcus multilocularis | cyclin B | 0.0302 | 0.2168 | 0.2168 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0276 | 0.1736 | 0.7726 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0307 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0276 | 0.1736 | 0.1736 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0307 | 0.2247 | 0.2247 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0307 | 0.2247 | 0.2247 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0307 | 0.2247 | 0.5 |
Leishmania major | cyclin | 0.0302 | 0.2168 | 0.8453 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.3 nM | Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligand | ChEMBL. | 11859005 |
Ki (binding) | = 0.3 nM | Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligand | ChEMBL. | 11859005 |
Ratio (binding) | = 5 | Binding affinity (Ki) of cloned human Muscarinic acetylcholine receptor M5 to the binding affinity (Ki) of Muscarinic acetylcholine receptor M2 | ChEMBL. | 11859005 |
Ratio (binding) | = 7 | Binding affinity (Ki) of cloned human Muscarinic acetylcholine receptor M4 to the binding affinity (Ki) of Muscarinic acetylcholine receptor M2 | ChEMBL. | 11859005 |
Ratio (binding) | = 17 | Binding affinity (Ki) of cloned human Muscarinic acetylcholine receptor M3 to the binding affinity (Ki) of Muscarinic acetylcholine receptor M2 | ChEMBL. | 11859005 |
Ratio (binding) | = 66 | Selectivity ratio of binding affinity (Ki) of cloned human muscarinic acetylcholine receptor M1 to the binding affinity (Ki) of muscarinic acetylcholine receptor M2 | ChEMBL. | 11859005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.