Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gonadotropin-releasing hormone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | GnHR receptor homolog | Get druggable targets OG5_131719 | All targets in OG5_131719 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | telomerase reverse transcriptase | 0.0816 | 0.2712 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0008 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0558 | 0.1847 | 0.2544 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0816 | 0.2712 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0008 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0816 | 0.2712 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0008 | 0 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0816 | 0.2712 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0008 | 0 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.2173 | 0.7261 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0816 | 0.2712 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0816 | 0.2712 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0008 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0816 | 0.2712 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0816 | 0.2712 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 400 nM | Binding affinity was determined towards human gonadotropin-releasing hormone receptor | ChEMBL. | 12747774 |
Ki (binding) | = 400 nM | Binding affinity evaluated by the ability to inhibit des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned human Gonadotropin-releasing hormone receptor expressed in HEK293 cells | ChEMBL. | 14971906 |
Ki (binding) | = 400 nM | Binding affinity was determined towards human gonadotropin-releasing hormone receptor | ChEMBL. | 12747774 |
Ki (binding) | = 400 nM | Binding affinity evaluated by the ability to inhibit des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned human Gonadotropin-releasing hormone receptor expressed in HEK293 cells | ChEMBL. | 14971906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.