Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.0548 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0369 | 0.0505 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.1952 | 0.3672 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.1952 | 0.3672 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.1952 | 0.3672 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.1952 | 0.3672 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.5116 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.5116 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0246 | 0.0258 | 0.4569 |
Mycobacterium ulcerans | peptide deformylase | 0.5116 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.5116 | 1 | 1 |
Brugia malayi | Hemopexin family protein | 0.0144 | 0.0055 | 0.1666 |
Loa Loa (eye worm) | matrixin family protein | 0.0225 | 0.0217 | 0.3807 |
Onchocerca volvulus | Matrilysin homolog | 0.0225 | 0.0217 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0204 | 0.0175 | 0.3473 |
Treponema pallidum | polypeptide deformylase (def) | 0.5116 | 1 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.5116 | 1 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.1952 | 0.3672 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0246 | 0.0258 | 1 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0186 | 0.0138 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.1952 | 0.3672 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.1952 | 0.3672 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0225 | 0.0217 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.5116 | 1 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0186 | 0.0138 | 0.2739 |
Toxoplasma gondii | hypothetical protein | 0.5116 | 1 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0369 | 0.0505 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease in blood pressure (functional) | = 10 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 12-18 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 10 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 12-18 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 12 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 0-6 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 12 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 6-12 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 12 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 0-6 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
Decrease in blood pressure (functional) | = 12 % | Percentage decrease in blood pressure at a dose of 135 microM/kg for 6-12 h in spontaneously hypertensive rats. | ChEMBL. | 1311765 |
IC50 (functional) | = 9.2 uM | Concentration required to cause 50% relaxation of maximal contraction in circumferential rabbit aorta strips in response to KCl (100 mM) | ChEMBL. | 1311765 |
logP (ADMET) | = 1.6 | Partition coefficient (logP) | ChEMBL. | 1311765 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.