Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.0654 | 0.2314 | 0.2314 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0607 | 0.1718 | 0.1718 |
Schistosoma mansoni | glutamate receptor NMDA | 0.1125 | 0.8282 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0654 | 0.2314 | 0.2314 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0746 | 0.3478 | 0.3478 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1261 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0746 | 0.3478 | 0.3478 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.31 mM kg-1 | Compound was evaluated for protection against tachycardia in mice | ChEMBL. | 7277383 |
ED50 (functional) | = 0.31 mM kg-1 | Compound was evaluated for protection against tachycardia in mice | ChEMBL. | 7277383 |
ED50 (functional) | = 1.81 mM kg-1 | Compound was evaluated for ataxia in mice | ChEMBL. | 7277383 |
ED50 (functional) | = 1.81 mM kg-1 | Compound was evaluated for ataxia in mice | ChEMBL. | 7277383 |
logP (ADMET) | = 1.02 | Partition coefficient (logP) | ChEMBL. | 7277383 |
pKa | = 9.81 | Dissociation constant (pKa) | ChEMBL. | 7277383 |
p[BH+50] (ADMET) | = 0.51 | Compound was evaluated for -Log [fraction ionized x ED50 (protection)] | ChEMBL. | 7277383 |
TI (functional) | = 5.8 | Therapeutic index is the ratio of ED50 (ataxia) to ED50 (protection) in mice | ChEMBL. | 7277383 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.