Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Peptide deformylase 2 | 0.0354 | 0 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0928 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0928 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0928 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0928 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0354 | 0 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0354 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0354 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0354 | 0 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 0.6877 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0354 | 0 | 0.5 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0749 | 0.6877 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0354 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0928 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0928 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0928 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0928 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration (functional) | = 0 min | The time to 50% recovery of the angiotensin I response was measured after po administration of the compound at 1.5 mg/kg; 0-30 | ChEMBL. | 3009814 |
Duration (functional) | = 0 min | The time to 50% recovery of the angiotensin I response was measured after po administration of the compound at 1.5 mg/kg; 0-30 | ChEMBL. | 3009814 |
I50 (binding) | = 15 uM | In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung | ChEMBL. | 3009814 |
I50 (binding) | = 50 uM | In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung | ChEMBL. | 3009814 |
IC50 (binding) | = 15 uM | In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung | ChEMBL. | 3009814 |
IC50 (binding) | = 50 uM | In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung | ChEMBL. | 3009814 |
Inhibition (functional) | = 0 % | Percentage inactivation of the angiotensin I induced vasopressor response in normotensive conscious rats after po administration at dose 1.5 mg/kg; 0-29 | ChEMBL. | 3009814 |
Inhibition (functional) | = 0 % | Percentage inactivation of the angiotensin I induced vasopressor response in normotensive conscious rats after po administration at dose 1.5 mg/kg; 0-29 | ChEMBL. | 3009814 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.