Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.0357 | 0.6444 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0306 | 0.5211 | 0.8086 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | 0.0357 | 0.6444 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0165 | 0.1747 | 0.271 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0357 | 0.6444 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0502 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0174 | 0.1977 | 0.3068 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0165 | 0.1747 | 0.271 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0146 | 0.128 | 0.1986 |
Brugia malayi | dihydrofolate reductase family protein | 0.0146 | 0.128 | 0.1986 |
Schistosoma mansoni | tyrosine kinase | 0.0163 | 0.1704 | 0.2645 |
Brugia malayi | Protein kinase domain containing protein | 0.0098 | 0.0116 | 0.0181 |
Schistosoma mansoni | tyrosine kinase | 0.0165 | 0.1747 | 0.271 |
Brugia malayi | thymidylate synthase | 0.0357 | 0.6444 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0357 | 0.6444 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0165 | 0.1747 | 0.271 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0098 | 0.0116 | 0.0181 |
Echinococcus multilocularis | 0.0095 | 0.0041 | 0.0064 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0146 | 0.128 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0357 | 0.6444 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0098 | 0.0116 | 0.0181 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0306 | 0.5211 | 0.8086 |
Echinococcus granulosus | insulin receptor | 0.0098 | 0.0116 | 0.0181 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0146 | 0.128 | 0.1986 |
Echinococcus multilocularis | insulin receptor | 0.0098 | 0.0116 | 0.0181 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0357 | 0.6444 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0306 | 0.5211 | 0.8086 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0502 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0357 | 0.6444 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0502 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1977 | 0.3068 |
Brugia malayi | hypothetical protein | 0.017 | 0.1872 | 0.2906 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0165 | 0.1747 | 0.271 |
Schistosoma mansoni | tyrosine kinase | 0.0163 | 0.1704 | 0.2645 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0502 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0098 | 0.0116 | 0.0181 |
Schistosoma mansoni | dihydrofolate reductase | 0.0146 | 0.128 | 0.1986 |
Loa Loa (eye worm) | thymidylate synthase | 0.0357 | 0.6444 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0146 | 0.128 | 0.1986 |
Trichomonas vaginalis | conserved hypothetical protein | 0.017 | 0.1872 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0502 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0146 | 0.128 | 0.1986 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0306 | 0.5211 | 0.8086 |
Echinococcus multilocularis | geminin | 0.0174 | 0.1977 | 0.3068 |
Schistosoma mansoni | tyrosine kinase | 0.0306 | 0.5211 | 0.8086 |
Schistosoma mansoni | tyrosine kinase | 0.0098 | 0.0116 | 0.0181 |
Mycobacterium tuberculosis | Hypothetical protein | 0.017 | 0.1872 | 0.1148 |
Schistosoma mansoni | tyrosine kinase | 0.0163 | 0.1704 | 0.2645 |
Schistosoma mansoni | tyrosine kinase | 0.0098 | 0.0116 | 0.0181 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1977 | 0.3068 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.