Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Acyl-CoA:cholesterol acyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma japonicum | ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus granulosus | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma mansoni | sterol O-acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | diacylglycerol O-acyltransferase 1 | Acyl-CoA:cholesterol acyltransferase | 305 aa | 278 aa | 21.9 % |
Neospora caninum | sterol O-acyltransferase, putative | Acyl-CoA:cholesterol acyltransferase | 305 aa | 258 aa | 20.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0059 | 0.1064 | 0.1668 |
Plasmodium vivax | topoisomerase I, putative | 0.0181 | 0.6378 | 0.5 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0181 | 0.6378 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.1042 | 0.1042 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0135 | 0.4394 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0059 | 0.1064 | 0.056 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.0533 | 0.0836 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0264 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1042 | 0.0538 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.1064 | 0.1064 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1042 | 0.9798 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0135 | 0.4394 | 0.4078 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0059 | 0.1064 | 1 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0264 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0181 | 0.6378 | 0.6378 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.8875 | 0.8785 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0181 | 0.6378 | 0.6174 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0181 | 0.6378 | 0.609 |
Brugia malayi | hypoxia-induced factor 1 | 0.0145 | 0.4831 | 0.7574 |
Brugia malayi | hypothetical protein | 0.0158 | 0.5364 | 0.841 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0145 | 0.4831 | 0.4419 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1042 | 0.0538 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0135 | 0.4394 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0059 | 0.1064 | 0.1522 |
Plasmodium falciparum | topoisomerase I | 0.0181 | 0.6378 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1042 | 0.9798 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1042 | 0.9798 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.5364 | 0.4995 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.1042 | 0.1467 |
Brugia malayi | DNA topoisomerase I | 0.0181 | 0.6378 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.1042 | 0.1042 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0135 | 0.4394 | 0.4078 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.1064 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0181 | 0.6378 | 0.6378 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0059 | 0.1064 | 1 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0135 | 0.4394 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.039 uM | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in liver microsomes isolated from cholesterol-fed rabbits | ChEMBL. | 8145231 |
IC50 (binding) | = 0.039 uM | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in liver microsomes isolated from cholesterol-fed rabbits | ChEMBL. | 8145231 |
Reduction (functional) | = 42 % | In vivo hypocholesterolemic activity in golden hamsters, fed with a diet containing 2% cholesterol at a dose of 10 mg/kg,po | ChEMBL. | 8145231 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.