Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | References | |
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | integrin alpha 3 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 1032 aa | 873 aa | 22.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.0375 | 0.7305 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0268 | 0.4372 | 0.5985 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.016 | 0.1378 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0375 | 0.7305 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0352 | 0.669 | 0.669 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0268 | 0.4372 | 0.5985 |
Schistosoma mansoni | d-amino acid oxidase | 0.016 | 0.1378 | 0.1378 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.4695 | 0.6427 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0245 | 0.3726 | 0.51 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1378 | 0.1861 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0245 | 0.3726 | 0.51 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0129 | 0.0527 | 0.0722 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0147 | 0.1009 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.7406 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.3106 | 0.3106 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.016 | 0.1378 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.7406 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.4695 | 0.6427 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cl (ADMET) | = 3.9 K hr-1 | Rate of clearance of the compound using isolated perfused rat liver (IPRL) assay | ChEMBL. | 12617895 |
IC50 (binding) | = 5 nM | Inhibition of VLA-4 to VCAM-1 binding | ChEMBL. | 12617895 |
IC50 (binding) | = 5 nM | Inhibition of VLA-4 to VCAM-1 binding | ChEMBL. | 12617895 |
IC50 (binding) | = 140 nM | Inhibition of VLA-4 to VCAM-1 binding in Jurkat cell adhesion assay | ChEMBL. | 12617895 |
IC50 (binding) | = 140 nM | Inhibition of VLA-4 to VCAM-1 binding in Jurkat cell adhesion assay | ChEMBL. | 12617895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.