Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.048 | 1 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0247 | 0.2764 | 0.3594 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0275 | 0.3621 | 0.4709 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0405 | 0.7689 | 1 |
Schistosoma mansoni | d-amino acid oxidase | 0.048 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0405 | 0.7689 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0275 | 0.3621 | 0.1741 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.044 | 0.8756 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.048 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | NA 0 % | Percent inhibition of the leukotriene E4 (LTED4)-induced contraction of guinea pig tracheal spirals at 1 microM concentration ; NS means data was not statistically significant. | ChEMBL. | 2704027 |
Inhibition (functional) | = 73 % | Percent inhibition of the leukotriene E4 (LTE4)-induced contraction of guinea pig tracheal spirals at 5 microM concentration | ChEMBL. | 2704027 |
Inhibition (functional) | = 97 % | Percent inhibition of the leukotriene E4 (LTE4)-induced contraction of guinea pig tracheal spirals at 10 microM concentration | ChEMBL. | 2704027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.