Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | rap1 and, putative | 0.0236 | 1 | 0.5 |
Entamoeba histolytica | Ras family GTPase | 0.0236 | 1 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0057 | 0 | 0.5 |
Entamoeba histolytica | ras-1, putative | 0.0236 | 1 | 0.5 |
Trichomonas vaginalis | rheb, putative | 0.0236 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0057 | 0 | 0.5 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0236 | 1 | 0.5 |
Echinococcus multilocularis | ras gtpase | 0.0236 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | ral, putative | 0.0236 | 1 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0057 | 0 | 0.5 |
Echinococcus granulosus | ras gtpase | 0.0236 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0236 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0057 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0236 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | dexras1, putative | 0.0236 | 1 | 0.5 |
Entamoeba histolytica | Ras family GTPase | 0.0236 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0057 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0057 | 0 | 0.5 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Activation of human TRESK channel expressed in HEK293 cells assessed as induction of channel current at 100 uM by whole cell patch clamp assay relative to control | LITERATURE. | 27641472 | |
clogP | = 4.303 | Calculated partition coefficient (clogP) | ChEMBL. | 8487264 |
Inhibition (functional) | = 11.6 % | Compound is evaluated for the inhibition of [125I]-T3 uptake by H4 rat hepatoma cells at 0.1 mM | ChEMBL. | 8487264 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.