Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.5 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0095 | 0.5 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0095 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0095 | 0.5 | 0.5 |
Echinococcus multilocularis | laminin | 0.0095 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.5 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0095 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0095 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.5 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0095 | 0.5 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0095 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0095 | 0.5 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0095 | 0.5 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0095 | 0.5 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0095 | 0.5 | 0.5 |
Echinococcus granulosus | laminin | 0.0095 | 0.5 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0095 | 0.5 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.0095 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 55 nM | In vitro inhibition of [35S]-TBPS binding to gamma-aminobutyric-acid A receptor in rat brain cortical membranes in the presence of 5 microM GABA. | ChEMBL. | 9016330 |
Imax (functional) | = 96 % | The maximum inhibitory potency was calculated by fitting [35S]-TBPS inhibition data to a sigmoid function (rat brain cortical P2 membranes) | ChEMBL. | 9016330 |
PTZ protection (functional) | = 38 % | Percent of animals (n=8) not exhibiting PTZ-induced ( Pentylentetrazol protection) seizures 10 min following a 10 mg/kg ip dose of steroid. | ChEMBL. | 9016330 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.