Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 822 aa | 23.2 % |
Drosophila melanogaster | Glutamate receptor IA | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 979 aa | 23.7 % |
Drosophila melanogaster | NMDA receptor 2 | Glutamate (NMDA) receptor subunit zeta 1 | 938 aa | 878 aa | 27.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.01 | 0.5153 | 0.5153 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.01 | 0.5153 | 0.5153 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0071 | 0 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0071 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.4339 | 0.4339 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0071 | 0 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0071 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.4339 | 0.4339 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0071 | 0 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0071 | 0 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0071 | 0 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0071 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0071 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0109 | 0.6742 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3.7 mg kg-1 | Effective dose of the compound to inhibit convulsions induced by NMDA in mice, when administered intravenous route. | ChEMBL. | 9083472 |
ED50 (functional) | = 3.7 mg kg-1 | Effective dose of the compound to inhibit convulsions induced by NMDA in mice, when administered intravenous route. | ChEMBL. | 9083472 |
Ki (binding) | = -7.6 | Inhibition of [3H]-glycine to glycine binding site, associated with the N-methyl-D-aspartate glutamate receptor 1 in crude synaptic membranes prepared from adult rat cerebral cortex. | ChEMBL. | 9083472 |
Log Ki (binding) | = 7.6 | Inhibition of [3H]-glycine to glycine binding site, associated with the N-methyl-D-aspartate glutamate receptor 1 in crude synaptic membranes prepared from adult rat cerebral cortex. | ChEMBL. | 9083472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.