Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | O-methyltransferase family protein | 0.0038 | 0.0662 | 0.0662 |
Brugia malayi | O-methyltransferase family protein | 0.0038 | 0.0662 | 0.0662 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0038 | 0.0662 | 0.5 |
Schistosoma mansoni | o-methyltransferase | 0.0038 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | O-methyltransferase | 0.0038 | 0.0662 | 0.0662 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.0038 | 0.0662 | 0.5 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.0326 | 0.7093 | 1 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0457 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0662 | 0.0662 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0457 | 1 | 1 |
Onchocerca volvulus | 0.0038 | 0.0662 | 1 | |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0457 | 1 | 1 |
Schistosoma mansoni | o-methyltransferase | 0.0038 | 0.0662 | 0.0662 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0457 | 1 | 1 |
Brugia malayi | O-methyltransferase family protein | 0.0038 | 0.0662 | 0.0662 |
Schistosoma mansoni | o-methyltransferase | 0.0038 | 0.0662 | 0.0662 |
Schistosoma mansoni | o-methyltransferase | 0.0038 | 0.0662 | 0.0662 |
Onchocerca volvulus | 0.0038 | 0.0662 | 1 | |
Brugia malayi | O-methyltransferase | 0.0038 | 0.0662 | 0.0662 |
Mycobacterium ulcerans | O-methyltransferase | 0.0364 | 0.7936 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.85 uM | Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts | ChEMBL. | 10715151 |
Max increase (functional) | = 4 % | In vitro stimulation of 2PY1 purinoceptor mediated phospholipase C (PLC) activity in Turkey Erythrocyte Ghosts | ChEMBL. | 10715151 |
Max inhibition (functional) | = 96 % | Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts | ChEMBL. | 10715151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.