Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | adenosine kinase-like protein | Adenosine kinase | 361 aa | 351 aa | 36.8 % |
Schistosoma mansoni | ribokinase | Adenosine kinase | 361 aa | 289 aa | 23.2 % |
Candida albicans | similar to Ribokinase | Adenosine kinase | 361 aa | 309 aa | 20.7 % |
Leishmania mexicana | adenosine kinase-like protein | Adenosine kinase | 361 aa | 344 aa | 36.6 % |
Candida albicans | similar to Ribokinase | Adenosine kinase | 361 aa | 303 aa | 21.5 % |
Leishmania donovani | adenosine kinase-like protein | Adenosine kinase | 361 aa | 351 aa | 37.6 % |
Leishmania infantum | adenosine kinase-like protein | Adenosine kinase | 361 aa | 351 aa | 37.6 % |
Leishmania braziliensis | adenosine kinase-like protein | Adenosine kinase | 361 aa | 351 aa | 37.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 1 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 1 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.0105 | 1 | 0.5 |
Echinococcus granulosus | adenosine kinase | 0.0105 | 1 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 1 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 1 | 0.5 |
Echinococcus multilocularis | adenosine kinase | 0.0105 | 1 | 0.5 |
Onchocerca volvulus | 0.0093 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 1 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 1 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0105 | 1 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 uM kg-1 | Tested for analgesic activity in vivo rat formalin nociception assay, administered by intraperitoneal injection to six animals at each dose; Not tested | ChEMBL. | 11140740 |
ED50 (functional) | = 30 uM kg-1 | Tested for analgesic activity in vivo rat carrageenan hyperalgesia assay,administered by intraperitoneal injection to six animals at each dose . p<0.05 | ChEMBL. | 11140740 |
IC50 (binding) | = 9 nM | Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assay | ChEMBL. | 11140740 |
IC50 (binding) | = 9 nM | Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assay | ChEMBL. | 11140740 |
IC50 (binding) | = 115 nM | Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assay | ChEMBL. | 11140740 |
IC50 (binding) | = 115 nM | Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assay | ChEMBL. | 11140740 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.