Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 3 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 2 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 5 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 4 | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133264 | All targets in OG5_133264 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0165 | 0.0836 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.4097 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0082 | 0.0063 | 0.0155 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0438 | 0.3381 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0075 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0075 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1147 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0438 | 0.3381 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1147 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0836 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0836 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.1147 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0082 | 0.0063 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.1147 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0438 | 0.3381 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1147 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.1147 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1147 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.1147 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0165 | 0.0836 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0438 | 0.3381 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0438 | 0.3381 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0438 | 0.3381 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.4097 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0794 | 0.6711 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0438 | 0.3381 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -7.01 | Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Ki (binding) | = -6.62 | Binding affinity towards cloned human muscarinic acetylcholine receptor M1 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Ki (binding) | = -6.51 | Binding affinity towards cloned human muscarinic acetylcholine receptor M3 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Ki (binding) | = -6.18 | Binding affinity towards cloned human muscarinic acetylcholine receptor M4 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Ki (binding) | = -6.17 | Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Log Ki (binding) | = 6.17 | Binding affinity towards cloned human muscarinic acetylcholine receptor M5 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Log Ki (binding) | = 6.18 | Binding affinity towards cloned human muscarinic acetylcholine receptor M4 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Log Ki (binding) | = 6.51 | Binding affinity towards cloned human muscarinic acetylcholine receptor M3 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Log Ki (binding) | = 6.62 | Binding affinity towards cloned human muscarinic acetylcholine receptor M1 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Log Ki (binding) | = 7.01 | Binding affinity towards cloned human muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells using [3H]-N-methylscopolamine | ChEMBL. | 12593665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.