Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Enterobacter cloacae | Beta-lactamase class C | Starlite/ChEMBL | References |
Enterobacter cloacae | Beta-lactamase TEM | Starlite/ChEMBL | References |
Staphylococcus aureus | Beta-lactamase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | Get druggable targets OG5_143180 | All targets in OG5_143180 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | Get druggable targets OG5_143180 | All targets in OG5_143180 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | beta lactamase | Beta-lactamase | 281 aa | 279 aa | 31.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1846 | 1 | 1 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0154 | 0 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1095 | 0.5561 | 0.1678 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1846 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1846 | 1 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1095 | 0.5561 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.0732 | 0.7436 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0321 | 0.0985 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1095 | 0.5561 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1095 | 0.5561 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1846 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1095 | 0.5561 | 0.5 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0321 | 0.0985 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.07 uM | Inhibition of class A TEM-1 beta-lactamase derived from Enterobacter cloacae | ChEMBL. | 10853646 |
IC50 (binding) | = 0.07 uM | Inhibition of class A TEM-1 beta-lactamase derived from Enterobacter cloacae | ChEMBL. | 10853646 |
IC50 (binding) | = 0.18 uM | Inhibition of GC1 extended spectrum class C beta-lactamase | ChEMBL. | 10853646 |
IC50 (binding) | = 0.18 uM | Inhibition of GC1 extended spectrum class C beta-lactamase | ChEMBL. | 10853646 |
IC50 (binding) | = 0.9 uM | Inhibition of class C beta-lactamase derived from Enterobacter cloacae P99 | ChEMBL. | 10853646 |
IC50 (binding) | = 0.9 uM | Inhibition of class C beta-lactamase derived from Enterobacter cloacae P99 | ChEMBL. | 10853646 |
IC50 (binding) | = 1.4 uM | Inhibition of class A beta-lactamase derived from Staphylococcus aureus strain PC1 | ChEMBL. | 10853646 |
IC50 (binding) | = 1.4 uM | Inhibition of class A beta-lactamase derived from Staphylococcus aureus strain PC1 | ChEMBL. | 10853646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.