Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.16 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.16 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.16 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.16 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.16 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.16 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.16 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.16 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.16 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.16 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.16 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.16 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Equieffective dose (functional) | = 0.64 mg kg-1 | Compound was tested for inotropic activity by measuring the concentration required to increase cardiac contractile force by 30% in the anesthetized dog after intravenous administration | ChEMBL. | 3701794 |
Equieffective dose (functional) | > 3 mg kg-1 | Compound was tested for inotropic activity by measuring the concentration required to increase heart rate by 15% in the anesthetized dog after intravenous administration | ChEMBL. | 3701794 |
Equieffective dose (functional) | > 3 mg kg-1 | Compound was tested for inotropic activity by measuring the concentration required to mean blood pressure by 20% in the anesthetized dog after intravenous administration | ChEMBL. | 3701794 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.