Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.196 | 0.196 |
Plasmodium falciparum | carbonic anhydrase | 0.0108 | 0.2093 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0199 | 1 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0119 | 0.3023 | 0.1177 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2093 | 0.2093 |
Brugia malayi | Peptidase family M1 containing protein | 0.0119 | 0.3023 | 0.1177 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0096 | 0.1063 | 0.1063 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0199 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0199 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0199 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0108 | 0.2093 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0108 | 0.2093 | 0.2093 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2093 | 0.2093 |
Echinococcus granulosus | aminopeptidase N | 0.0119 | 0.3023 | 0.1177 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0199 | 1 | 0.5 |
Onchocerca volvulus | 0.0119 | 0.3023 | 0.5 | |
Leishmania major | carbonic anhydrase-like protein | 0.0199 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0199 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2093 | 0.2093 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0199 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0199 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 30 uM | Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain | ChEMBL. | 1849994 |
Ki (binding) | > 30 uM | Inhibition of strychnine-insensitive [3H]-glycine binding to the N-methyl-D-aspartate glutamate receptor of synaptic plasma membranes(SPM) prepared from rat forebrain | ChEMBL. | 1849994 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.