Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative organic anion transporter | 0.0416 | 0.5236 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0104 | 0.0776 | 0.0861 |
Brugia malayi | prostaglandin transporter | 0.0416 | 0.5236 | 0.5236 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0104 | 0.0776 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.1386 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0104 | 0.0776 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.1386 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.068 | 0.9014 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0104 | 0.0776 | 0.0861 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0104 | 0.0776 | 0.0776 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.068 | 0.9014 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.1386 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.5236 | 0.5236 |
Schistosoma mansoni | microtubule-associated protein tau | 0.068 | 0.9014 | 1 |
Brugia malayi | thymidylate synthase | 0.0104 | 0.0776 | 0.0776 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0147 | 0.1386 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.1386 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0147 | 0.1386 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0104 | 0.0776 | 0.0861 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0104 | 0.0776 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 nM | In vitro inhibition of Angiotensin I converting enzyme | ChEMBL. | 6310112 |
IC50 (binding) | = 11 nM | In vitro inhibition of Angiotensin I converting enzyme | ChEMBL. | 6310112 |
IC50 (binding) | = 0.023 uM | In vitro inhibitory activity of the compound against rabbit lung Angiotensin I converting enzyme at pH 8.3 | ChEMBL. | 2981324 |
IC50 (binding) | = 0.023 uM | In vitro inhibitory activity of the compound against rabbit lung Angiotensin I converting enzyme at pH 8.3 | ChEMBL. | 2981324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.