Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Corticotropin releasing factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Corticotropin releasing factor receptor | 411 aa | 330 aa | 22.7 % |
Loa Loa (eye worm) | hypothetical protein | Corticotropin releasing factor receptor | 411 aa | 394 aa | 29.4 % |
Onchocerca volvulus | Corticotropin releasing factor receptor | 411 aa | 388 aa | 31.2 % | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | Corticotropin releasing factor receptor | 411 aa | 400 aa | 25.8 % |
Onchocerca volvulus | Pseudouridine-5 prime-monophosphatase homolog | Corticotropin releasing factor receptor | 411 aa | 402 aa | 27.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | rheb, putative | 0.0237 | 1 | 0.5 |
Trichomonas vaginalis | ral, putative | 0.0237 | 1 | 0.5 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0237 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0062 | 0.0282 | 0.0282 |
Entamoeba histolytica | ras-1, putative | 0.0237 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.009 | 0.187 | 0.187 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.009 | 0.187 | 0.187 |
Entamoeba histolytica | Ras family GTPase | 0.0237 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.009 | 0.187 | 0.187 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0237 | 1 | 1 |
Entamoeba histolytica | Ras family GTPase | 0.0237 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0282 | 0.0282 |
Echinococcus multilocularis | ras gtpase | 0.0237 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 1 | 1 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0237 | 1 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | dexras1, putative | 0.0237 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.187 | 0.187 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0282 | 1 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0057 | 0 | 0.5 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0237 | 1 | 0.5 |
Echinococcus granulosus | ras gtpase | 0.0237 | 1 | 1 |
Trichomonas vaginalis | rap1 and, putative | 0.0237 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.