Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin-converting enzyme | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Brugia malayi | Angiotensin-converting enzyme family protein | Get druggable targets OG5_131988 | All targets in OG5_131988 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0664 | 0.04 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0405 | 0.0144 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3965 | 0.3658 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0442 | 0.018 | 0.3732 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3965 | 0.3658 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 1.039 | 1 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0414 | 0.0153 | 0.3812 |
Toxoplasma gondii | hypothetical protein | 1.039 | 1 | 0.5 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0749 | 0.0483 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0455 | 0.0194 | 0.4832 |
Loa Loa (eye worm) | matrixin family protein | 0.0442 | 0.018 | 0.0786 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0405 | 0.0144 | 1 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0414 | 0.0153 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 1.039 | 1 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3965 | 0.3658 | 0.5 |
Plasmodium falciparum | peptide deformylase | 1.039 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 1.039 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 1.039 | 1 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0664 | 0.04 | 1 |
Mycobacterium ulcerans | peptide deformylase | 1.039 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 1.039 | 1 | 1 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 0.0483 | 0.7391 |
Loa Loa (eye worm) | hypothetical protein | 0.087 | 0.0603 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3965 | 0.3658 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3965 | 0.3658 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3965 | 0.3658 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3965 | 0.3658 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.