Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.2519 | 0.2668 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.2514 | 0.266 | 0.1773 |
Loa Loa (eye worm) | hypothetical protein | 0.2519 | 0.2668 | 0.1789 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.2068 | 0.1947 | 0.7318 |
Brugia malayi | Matrixin family protein | 0.4582 | 0.5969 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.2519 | 0.2668 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.4587 | 0.5977 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.2519 | 0.2668 | 0.1793 |
Loa Loa (eye worm) | matrixin family protein | 0.4582 | 0.5969 | 0.998 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.4587 | 0.5977 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.7101 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.4587 | 0.5977 | 1 |
Onchocerca volvulus | 0.2514 | 0.266 | 0.177 | |
Mycobacterium ulcerans | hydrolase | 0.2519 | 0.2668 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2774 | 0.3076 | 0.2801 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.132 | 0.0749 | 0.2817 |
Schistosoma mansoni | hypothetical protein | 0.2514 | 0.266 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 57 % | Inhibition of passive cutaneous anaphylaxis following 30 mg/kg p.o. administration. | ChEMBL. | 6229634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.