Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0063 | 0 | 0.5 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0063 | 0 | 0.5 |
Trichomonas vaginalis | dexras1, putative | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0264 | 1 | 1 |
Echinococcus granulosus | ras gtpase | 0.0264 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0063 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0264 | 1 | 1 |
Entamoeba histolytica | Ras family GTPase | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0063 | 0 | 0.5 |
Trichomonas vaginalis | rap1 and, putative | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0063 | 0 | 0.5 |
Entamoeba histolytica | Ras family GTPase | 0.0264 | 1 | 0.5 |
Trichomonas vaginalis | rheb, putative | 0.0264 | 1 | 0.5 |
Entamoeba histolytica | ras-1, putative | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0063 | 0 | 0.5 |
Echinococcus multilocularis | ras gtpase | 0.0264 | 1 | 1 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0063 | 0 | 0.5 |
Trichomonas vaginalis | ral, putative | 0.0264 | 1 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0063 | 0 | 0.5 |
Onchocerca volvulus | 0.0063 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0063 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = 39.8 % | Percent decrease in serum cholesterol relative to OVX controls, at 0.01 mg/Kg compound dose | ChEMBL. | 9548817 |
Decrease (functional) | = 65.5 % | Percent decrease in serum cholesterol relative to OVX controls, at 1.0 mg/Kg compound dose | ChEMBL. | 9548817 |
ED50 (functional) | = 0.7 mg kg-1 | Dose required to reduce serum cholesterol by 50% relative to ovariectomized(OVX) controls | ChEMBL. | 9548817 |
IC50 (functional) | = 80 nM | Inhibition of estrogen-stimulated MCF-7 cell proliferation | ChEMBL. | 9548817 |
IC50 (functional) | = 80 nM | Inhibition of estrogen-stimulated MCF-7 cell proliferation | ChEMBL. | 9548817 |
MED (functional) | = 0.1 mg kg-1 | Minimally effective dose(MED) (mg/kg body weight) at which a statistically significant (p<= 0.05) increase in uterine weight/body weight was observed | ChEMBL. | 9548817 |
MED (functional) | = 0.1 mg kg-1 | Minimally effective dose(MED) (mg/kg body weight) at which a statistically significant (p<= 0.05) increase in uterine weight/body weight was observed | ChEMBL. | 9548817 |
MED (functional) | > 10 mg kg-1 | Minimally effective dose(MED) (mg/kg body weight) at which a significant increase in EPO activity was observed in rats | ChEMBL. | 9548817 |
RBA (binding) | = 0.01 | Relative binding affinity of Estrogen receptor measured by using [3H]-17-beta-estradiol | ChEMBL. | 9548817 |
RBA (binding) | = 0.01 | Relative binding affinity to estrogen receptor | ChEMBL. | 22405286 |
RBA (binding) | = 0.01 | Relative binding affinity of Estrogen receptor measured by using [3H]-17-beta-estradiol | ChEMBL. | 9548817 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9548817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.